Gut Liver.  2011 Jun;5(2):204-209.

Expression of the Transmembrane Glycoprotein CD44s Is Potentially an Independent Predictor of Recurrence in Hepatocellular Carcinoma

• Ryu HS
• Park SH
• Lee KB
• Shin E
• Jang JJ

Abstract

BACKGROUND/AIMS
Cluster differentiation 44 standard isoform (CD44s) is a transmembrane glycoprotein. CD44s is a known prognostic factor in various cancers, due to its involvement in tumor cell growth, invasion and metastasis. Its prognostic role, however, is debated because it can be a positive or negative prognostic factor depending on tumor type and is still an ambiguous prognostic indicator in other cancers, especially hepatocellular carcinoma (HCC). We investigated the relationship between CD44s expression and survival in HCC patients.
METHODS
A total of 260 HCC samples were collected to generate a tissue microarray. Staining of the arrays with a primary mouse CD44s monoclonal antibody was followed by evaluation of the relationship between CD44s expression and tumor differentiation. The effect of CD44s expression on patient survival was analyzed.
RESULTS
CD44s protein expression correlated with histological grade (most and worst Edmondson grade) of the HCC (p=0.029 and p=0.039, respectively) and adversely affected the disease free survival period based on univariate and multivariate analyses (p=0.038 and p=0.077, respectively).
CONCLUSIONS
High CD44s protein expression correlates with shorter disease free survival and poorly differentiated HCC. CD44s-targeted therapy may be efficacious for HCC treatment in the future.

Keyword

Hepatocellular carcinoma; CD44s antigen; Protein microarrays

MeSH Terms

Animals
Antigens, CD44
Carcinoma, Hepatocellular
Disease-Free Survival
Glycoproteins
Humans
Mice
Multivariate Analysis
Neoplasm Metastasis
Protein Array Analysis
Recurrence
Antigens, CD44
Glycoproteins