Blood Res.  2015 Dec;50(4):204-217. 10.5045/br.2015.50.4.204.

Nationwide statistical analysis of myeloid malignancies in Korea: incidence and survival rate from 1999 to 2012

• Park EH
• Lee H
• Won YJ
• Ju HY
• Oh CM
• Ingabire C
• Kong HJ
• Park BK
• Yoon JY
• Eom HS
• Lee E
• Park HJ

• KMID: 2133755
• DOI: http://doi.org/10.5045/br.2015.50.4.204

Abstract

BACKGROUND
Large-scale epidemiologic analysis for hematologic malignancies will be helpful to understand the trends in incidence and survival.
METHODS
The Korea Central Cancer Registry (KCCR) updated the nationwide analysis on the incidence and survival of myeloid malignancies, from the Korean National Cancer Incidence Database between 1999 and 2012. Myeloid malignancies were classified based on the International Classification of Diseases for Oncology 3rd edition (ICD-O-3).
RESULTS
Overall 3,771 cases of myeloid diseases, which was 1.7% of all cancers, were identified in 2012. The highest incidence of myeloid malignancies was observed in age 70s and male predominance was noted (1.3:1). Acute myeloid leukemia (AML) was the most frequent subtype, followed by myeloproliferative neoplasms (MPN), myelodysplastic syndrome (MDS) and MDS/MPN: age-standardized incidence rates (ASR) in 2012 for each disease were 2.02, 1.95, 1.13, and 0.12 per 100,000 persons, respectively. The ASR for all myeloid malignancies was increased from 3.31 in 1999 to 5.70 in 2012 with the annual percentage change (APC) of 5.4 %. Five-year relative survival rate (RS) for myeloid malignancies has gradually improved for decades. RS changed from 26.3% to 34.8% in AML, specifically from 51.6% to 69.6% in acute promyelocytic leukemia (APL) and from 23.8% to 29.9% in non-APL AML, between 1996-2000 and 2008-2012. RS also increased from 81.8% to 87.1% in MPN, with a significant improvement in CML (from 74.5% to 85.5%), and from 27.3% to 31.7% in MDS/MPN between 2001-2005 and 2008-2012. However, there was no survival improvement in MDS during the study period (45.6% in 2001-2005 to 44.4% in 2008-2012).
CONCLUSION
This report updated the nationwide statistical analysis on myeloid malignancies since 2008, showing increasing incidence and improving trends in survival.

Keyword

Myeloid malignancy; Incidence; Survival; Korea

MeSH Terms

Hematologic Neoplasms
Humans
Incidence*
International Classification of Diseases
Korea*
Leukemia, Myeloid, Acute
Leukemia, Promyelocytic, Acute
Male
Myelodysplastic Syndromes
Survival Rate*

Figure

• 

  Fig. 1 Incident cases of myeloid malignancies in men (B) and women (C) in Korea, 2012. a)AML cases include 153 cases of APL in both genders (77 cases in men, and 76 cases in women); b)MPN cases include 458 cases of CML in both genders (288 cases in men, and 170 cases in women); c)Unknown cases include 15 cases of acute leukemia, ambiguous lineage in both genders (7 cases in men, 8 cases in women).Abbreviations: AML, acute myeloid leukemia; MPN, myeloproliferative neoplasms; MDS, myelodysplastic syndrome; MDS/MPN, myelodysplastic/myeloproliferative neoplasms.

• 

  Fig. 2 Incident cases of myeloid malignancies by age group in Korea, 2012.Abbreviations: same as in Fig. 1.

• 

  Fig. 3 Age-specific incidence rates of myeloid malignancies in men (A) and in women (B) in Korea, 2012.Abbreviations: same as in Fig. 1.

• 

  Fig. 4 Trend in relative survival rate of myeloid malignances between 1996 and 2010 in Korea.Abbreviations: same as in Fig. 1.

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