J Korean Med Sci.  2015 Mar;30(3):264-271. 10.3346/jkms.2015.30.3.264.

Relationship between Sarcopenic Obesity and Cardiovascular Disease Risk as Estimated by the Framingham Risk Score

• Kim JH
• Cho JJ
• Park YS

• KMID: 2133303
• DOI: http://doi.org/10.3346/jkms.2015.30.3.264

Abstract

This study was conducted to assess the association between sarcopenic obesity and cardiovascular disease (CVD) risk in Korean adults (n=3,320; > or =40 yr) who participated in the 5th Korean National Health and Nutrition Examination Survey in 2010. The appendicular skeletal muscle mass divided by body weight was calculated for each participant; participants with values <1 standard deviation below the mean reference value (i.e., aged 20-39 yr) were considered sarcopenic. Subjects were further classified into 4 groups according to their obesity (i.e., body mass index > or =25 kg/m2) and sarcopenic status. Individuals' 10-yr CVD risk was determined using the Framingham risk model. The sarcopenic obese group had more participants (43.8% men, 14.6% women) with a high risk of CVD (> or =20%). The sarcopenic obese group was associated with an increased 10-yr CVD risk than the non-sarcopenic, non-obese group (odds ratio [OR], 2.49; 95% confidence interval [CI], 1.53-4.06, P<0.001 in men; OR, 1.87; 95% CI, 1.02-3.41, P=0.041 in women). Sarcopenic non-obese and non-sarcopenic obese subjects were not associated with an increased 10-yr CVD risk. Sarcopenic obesity, but not non-sarcopenic obesity, was closely associated with an increased CVD risk in Korean adults.

Keyword

Sarcopenia; Obesity; Cardiovascular Diseases; Risk Assessment; KNHANES

MeSH Terms

Aging
Body Composition/physiology
Body Mass Index
Body Weight
Cardiovascular Diseases/*epidemiology
Cross-Sectional Studies
Diabetes Mellitus/epidemiology
Female
Humans
Male
Middle Aged
Muscle, Skeletal/*physiology
Obesity/*epidemiology
Risk
Risk Factors
Sarcopenia/*epidemiology
Sex Factors

Figure

• 

  Fig. 1 Framingham risk score category within sarcopenic obesity phenotype groups according to body mass index and sarcopenic status by sex (P < 0.001 across groups). Groups A (non-sarcopenic, non-obese), B (sarcopenic, non-obese), C (non-sarcopenic, obese), and D (sarcopenic, obese) are shown.

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