Tuberc Respir Dis.  2004 Aug;57(2):183-187. 10.4046/trd.2004.57.2.183.

Recurrent Secondary Pneumothorax Caused by Bronchiolitis Obliterans Due to Chronic Graft Versus Host Disease in a Patient with Chronic Myelogenous Leukemia after Allogenic Bone Marrow Transplantation

• Ahn CM
• Hwang SY
• Byun MK
• Lee JH
• Chung WY
• Moon JW
• Park MS
• Min YH
• Kim SK
• Chang J
• Kim SK
• Kim H
• Kim H
• Kim YS

• KMID: 2132501
• DOI: http://doi.org/10.4046/trd.2004.57.2.183

Abstract

Bronchiolitis obliterans (BO) is a nonspecific inflammatory injury affecting primarily the small airways. Its inflammatory process is characterized by fibrotic obliteration of the lumen of bronchioles. BO can be idiopathic or associated with connective tissue disease, inhaled toxins, infections, drugs, and chronic graft-versus-host-disease (GVHD). Pulmonary complications occur in 40~60% of patients who undergo allogeneic bone marrow transplantation (BMT), causing 10~40% of transplant-related deaths. BO is a characteristic pulmonary complication which occurs usually within a few years after BMT. Documented complications of BO include air-leak syndromes such as pneumomediastinum, subcutaneous emphysema and pneumothorax. We report a case of a 30-year-old male patient with BO due to chronic GVHD after allogenic BMT who presented with recurrent bilateral pneumothoraces.

Keyword

Bone marrow transplantation; Bronchiolitis obliterans; Graft-versus-host-disease; Pneumothorax; air-leak syndrome

MeSH Terms

Adult
Bone Marrow Transplantation*
Bone Marrow*
Bronchioles
Bronchiolitis Obliterans*
Bronchiolitis*
Connective Tissue Diseases
Graft vs Host Disease*
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*
Male
Mediastinal Emphysema
Pneumothorax*
Subcutaneous Emphysema
Transplants*