Tuberc Respir Dis.  2004 Feb;56(2):144-150. 10.4046/trd.2004.56.2.144.

The Time Responses of Spirometric Values in Response to Single Doses of Inhaled Salbutamol

• Park SH
• Choi WI
• Lee SW
• Park HP
• Seo YW
• Ku DH
• Lee MY
• Lee CW
• Jeon YJ

• KMID: 2132467
• DOI: http://doi.org/10.4046/trd.2004.56.2.144

Abstract

BACKGROUND: An assessment of the presence and the degree of reversibility of airflow obstruction is clinically important in patients with asthma or chronic obstructive pulmonary disease. However, the time responses of spirometric parameters in response to bronchodilator have not been well investigated.
METHODS
We studied 15 patients with asthma. Spirometric and mini-Wright peak expiratory flow measurements were performed at 15, 30, 45, and 60 minutes after using single dose(200 micro gram) of inhaled bronchodilator, salbutamol.
RESULTS
The mean values of forced expiratory volume in one second(FEV1) and forced vital capicaty(FVC) were significantly increased at 60 minutes after using bronchodilator in comparison to 15 minutes. And peak expiratory flow rate measured by either mass flow sensor or mini-Wright peak flow meter were significantly increased at 45 minutes after using bronchodilator in comparison to 15 minutes.
CONCLUSIONS
To appropriate evaluation of the bronchodilator response in patients with reversible airflow limitation, it would be useful measuring either FEV1 or PEF at the later time point 60 or 45 minutes in comparison to 15 minutes after using bronchodilator.

Keyword

PEF; FEV1; Reversibility of airflow obstruction; Salbutamol; Asthma

MeSH Terms

Albuterol*
Asthma
Forced Expiratory Volume
Humans
Peak Expiratory Flow Rate
Pulmonary Disease, Chronic Obstructive
Albuterol