Yonsei Med J.  2014 Jul;55(4):1036-1041. 10.3349/ymj.2014.55.4.1036.

Association between Serum 25-Hydroxyvitamin D Level and Insulin Resistance in a Rural Population

• Song BM
• Kim HC
• Choi DP
• Oh SM
• Suh I

• KMID: 2130830
• DOI: http://doi.org/10.3349/ymj.2014.55.4.1036

Abstract

PURPOSE
A low serum 25-hydroxyvitamin D [25(OH)D] level in the blood has been correlated with an increased risk of diabetes mellitus; however, the association between serum 25(OH)D level and insulin resistance has not been established in a Korean rural population. The aim of this study was to investigate the independent association between serum 25(OH)D level and insulin resistance in rural Korean adults.
MATERIALS AND METHODS
This study used data from the Korean Genome Epidemiology Study-Kangwha Study. In the 2011 study, 1200 adults completed health examinations. In an ancillary study, serum 25(OH)D level was measured in a subsample (n=813). After excluding those taking vitamin D supplements, a cross-sectional analysis was carried out on 807 participants (324 men and 483 women) aged 40 to 89 years old. Measured from overnight fasting blood samples, glucose and insulin levels were used to calculate the homeostasis model assessment for insulin resistance (HOMA-IR). Measures of glucose, insulin, and HOMA-IR were log-transformed for parametric tests.
RESULTS
Serum 25(OH)D level was inversely associated with HOMA-IR (beta=-0.003, p=0.039) in a univariate analysis. However, the association was not significant after adjustment for sex and age (beta=-0.002, p=0.123) or after adjustment for sex, age, body mass index, smoking status, alcohol intake, and regular exercise (beta=-0.003, p=0.247).
CONCLUSION
Our findings suggest that vitamin D is not independently associated with insulin resistance in Korean men and women.

Keyword

Vitamin D; insulin resistance; epidemiology

MeSH Terms

Adult
Aged
Aged, 80 and over
Asian Continental Ancestry Group
Cross-Sectional Studies
Female
Humans
Insulin Resistance/*physiology
Male
Middle Aged
Rural Population
Vitamin D/*analogs & derivatives/blood
Vitamin D Deficiency/blood/epidemiology
Vitamin D

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