Korean J Intern Med.  2015 Jan;30(1):104-109. 10.3904/kjim.2015.30.1.104.

Mortality in patients with rheumatoid arthritis-associated interstitial lung disease treated with an anti-tumor necrosis factor agent

• Koo BS
• Hong S
• Kim YJ
• Kim YG
• Lee CK
• Yoo B

• KMID: 2129670
• DOI: http://doi.org/10.3904/kjim.2015.30.1.104

Abstract

BACKGROUND/AIMS
To evaluate the impact on mortality of anti-tumor necrosis factor (anti-TNF) treatment of rheumatoid arthritis-associated interstitial lung disease (RA-ILD).
METHODS
We retrospectively reviewed the medical records of 100 RA-ILD patients who visited our tertiary care medical center between 2004 and 2011, identified those treated with an anti-TNF agent, divided patients into non-survivor and survivor groups and evaluated their clinical characteristics and causes of death.
RESULTS
A total of 24 RA-ILD patients received anti-TNF therapy, of whom six died (25%). Mean age at initiation of anti-TNF therapy was significantly higher in the nonsurvivor versus survivor group (76 years [range, 66 to 85] vs. 64 years [range, 50 to 81], respectively; p = 0.043). The mean duration of anti-TNF treatment in the non-survivor group was shorter (7 months [range, 2 to 14] vs. 23 months [range, 2 to 58], respectively; p = 0.030). The duration of anti-TNF therapy in all nonsurviving patients was < 12 months. Pulmonary function test results at ILD diagnosis, and cumulative doses of disease-modifying drugs and steroids, did not differ between groups. Five of the six deaths (83%) were related to lung disease, including two diffuse alveolar hemorrhages, two cases of acute exacerbation of ILD, and one of pneumonia. The sixth patient died of septic shock following septic arthritis of the knee.
CONCLUSIONS
Lung complications can occur within months of initial anti-TNF treatment in older RA-ILD patients; therefore, anti-TNF therapy should be used with caution in these patients.

Keyword

Arthritis, rheumatoid; Lung diseases, interstitial; Adalimumab; TNFR-Fc fusion protein; Infliximab

MeSH Terms

Adult
Aged
Aged, 80 and over
Antirheumatic Agents/adverse effects/*therapeutic use
Arthritis, Rheumatoid/complications/diagnosis/*drug therapy/immunology/mortality
Female
Humans
Lung Diseases, Interstitial/diagnosis/etiology/*mortality
Male
Middle Aged
Republic of Korea
Retrospective Studies
Risk Assessment
Risk Factors
Tertiary Care Centers
Time Factors
Treatment Outcome
Tumor Necrosis Factor-alpha/*antagonists & inhibitors
Antirheumatic Agents
Tumor Necrosis Factor-alpha