J Korean Med Sci.  2014 Aug;29(8):1077-1081. 10.3346/jkms.2014.29.8.1077.

Four-Week Effects of Allopurinol and Febuxostat Treatments on Blood Pressure and Serum Creatinine Level in Gouty Men

• Kim HA
• Seo YI
• Song YW

• KMID: 2129601
• DOI: http://doi.org/10.3346/jkms.2014.29.8.1077

Abstract

The aim of this study was to observe the effects of uric acid lowering therapy (UALT), febuxostat and allopurinol, on blood pressure (BP) and serum creatinine level. Post-hoc data were derived from a phase-III, randomised, double-blind, 4-week trial of male gouty patients that compared the safety and efficacy of febuxostat and allopurinol in adults with gout. The subjects were randomly assigned to one of five groups, 35-37 in each group (febuxostat: 40, 80, 120 mg/d; allopurinol: 300 mg/d; control group: placebo). Blood pressure and serum creatinine level were measured at baseline and at weeks 2 and 4. Diastolic BP and creatinine level had decreased significantly in the UALT groups compared to the control group at week 4. Diastolic BP had decreased significantly in the allopurinol group and serum creatinine level had decreased significantly in the febuxostat groups at week 4. After adjusting for confounding variables, serum uric acid changes were found to be significantly correlated with changes in serum creatinine level but were not associated with changes in systolic or diastolic BP. UALT in gouty subjects significantly decreased diastolic BP and serum creatinine level. Changes in uric acid were significantly correlated with those in serum creatinine level, suggesting the feasibility of renal function improvement through UALT in gouty men.

Keyword

Gout; Hyperuricemia; Allopurinol; Febuxostat; Creatinine; Blood Pressure

MeSH Terms

Allopurinol/*administration & dosage
Biological Markers/blood
Blood Pressure/*drug effects
Creatinine/*blood
Dose-Response Relationship, Drug
Gout/*drug therapy
Gout Suppressants/administration & dosage
Humans
Hypertension, Renal/diagnosis/etiology/*prevention & control
Male
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Thiazoles/*administration & dosage
Treatment Outcome
Allopurinol
Biological Markers
Creatinine
Gout Suppressants
Thiazoles

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