The Adequate Concentration of Subconjunctivally Injected Mitomycin c for the Prevention of Postoperative Adhesion in Strabisrnus

Kirn, Chan II; Kang, Seung Min; Cho, Yoonae A

Abstract

It. has been reported that, subconjunctival mitornycin c is strongiy effective in the reduction of postoperative fibrosis and adhesion. However we have to be cautious in using it clinically because of severe complications, scleral necrosis, endophthalmitis, etc. To find out the adequate concentration of mitomycin C, the authors performed 3mm recession of the superior rectus muscle (SR) in the left sys of 24 rabbits which were divided into 4 groups. Each group was composed of 6 rabbits. The 0.1%of 0.9% normal saline, 0.005% 0.01%, and 0.02% mitomycin c were injected subcounctivally through the site of SR recession in each group, respectively. The severity of the adhesion between SR and its surrounding tissues and the reduction of fibroblast. proliferation were evaluated histopathologically with the light microscope one month after surgery. The 0.01% and 0.02%mitomycin C-injected groups demonstrated considerable inhibition of postoperative adhesion and fibroblastic proliferation (p<0.05 and P<0.01, respectively) . However the 0. 005% mitomycin c was not. effective in the reduction of postoperative adhesion (P>0. 15), This study reveals that the concentration of mitomycin c between 0.01% and 0.02% may prevent postoperative adhesions effectively after strabisrnus surgery. Further studies are needed to demonstrate the lowest concentration of mitoniycin c to prevent postoperative adhesion effectively without any com.plicat.ions in clinical use.