J Korean Ophthalmol Soc.
1997 Feb;38(2):242-250.
Ganciclovir Treatment for Cytomegalovirus Retinitis in Renal Transplant Recipients
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- 1Department of Ophthalmology, School of Medice, Kyungpook National University, Taegu, Korea.
Abstract
- Two patients of cytomegalovirus(CMV) retinitis after renal transplantation were reviewed. And the clinical and virologic efficacy of ganciclovir in the treatment of severe CMV retinitis in renal transplant recipients was investigated. Diagnosis was based on the typical funduscopic appearance of CMV retinitis clinically, and the presence of CMV antibody IgG and IgM serologically. Two patients received ganciclovir intravenously at a dose of 100 to 600 mg/day for 46 to 52 days. Clinical stabilization or imporvement in the visual acuity and the lesion of retinitis ocurred in 2 patients within 1 month after the administration of ganciclovir. Mild or moderate decrease of white blood cell was the major side effect encountered during the administration of ganciclovir. By reducing the amount or stopping of ganciclovir, the number of the decreased white blood cell was increased rapidly above 2.000/mm^3 within 5 days. And none of these cases relapsed after the administration of ganciclovir for at least approximately 4 months. We conclude that ganciclovir treatment is clinically effective in improving CMV retinitis in renal transplant recipients.
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