J Korean Ophthalmol Soc.
1997 Aug;38(8):1336-1341.
Scanning Electron Microscopic Observation on the Microvasculature in Anterior Segment of the Rabbit Eye Injected with Endothelin-1
- Affiliations
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- 1Department of Ophthalmology, College of Medicine, Sung Kyun Kwan University, Masan Samsung Hospital.
- 2Department of Ophthalmology School of Medicine Gyeong Sang National University.
Abstract
- Using Mercox CL-2B, intravascular casting was performed follwoing intracameral injection with 2.0microgram/microliter of Endothelin-1(ET-1) in the rabbit eye. One hour after intracameral injection with ET-1 caused severe focal andsegmental constriction of major arterial circle(MAC). Obstruction of the small branch of MAC caused localized filling defect and decreased number of capillaries in the vascular cast. The diameters of vascular cast were reduced at about 22.2% in proximal MAC, 22.4% in distal MAC and 21.8% in first branch of MAC. This results were suggested that ET-1 may play a role in the regulation of blood flow in the anterior segment vasculature of the rabbit.
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