J Korean Ophthalmol Soc.  1987 Dec;28(6):1205-1217.

Changes of Corneal Endothelium and Surrounding Tissues After Implantation of IOLAB-IOL and UNI-IOL in Rabbit's eyes

• Ahn MD
• Kim JH

Abstract

The aim of this study was to evaluate the degree of tolerance of the rabbit's eye when UNI-IOL, prototype of posterior intraocular lens, manufactured in Korea was implanted into the rabbit's eye in comparison with that of the rabbit's eye when IOLAB-IOL manufactured in U.S.A. was implanted. Twenty two eyes of 22 rabbits were operated with extracapsular lens extraction using Healon(R). IOLAB-IOL was implanted into the 11 eyes(Group 1) while UNI-IOL was implanted into another 11 eyes(Group 2). Clinical observation was performed for 5 months and corneal thickness and endothelial cell density were measured. Several eyes were enucleated and their ultrastructural changes were observed with light and electron microscopes. The results are as follows: 1. Clinical observation by slit lamp biomicroscope revealed that inflammatory reaction in the anterior chamber in group 1 and 2 decreased gradually until post operative 10th day and almost disappeared by the post-operative 14 th day. With regard to postoperative complication, there were 2 cases of hyphema in group 1 and 1 case in group 2 and 1 case of wound leaking in group 2 in the early stage. In the later stage, 2 cases of posterior synechia in each group and 1 case of anterior displacement of optic of PCL in group 2 were observed. 2. Corneal thickness of group 1 and 2 increased by 33.5% and 35.9% respectively on the postoperative 1st day and increased most on the postoperative 3 rd day. Then it began to decrease and reached the level of 17.2% and 21.7% respectively on the postoperative 7th day. After 28 days after the operation it decreased to 5.5% and 7.7%, 3 months after the operation 1.5% and 2.4% and 5 months after the operation 1.3% and 2.1% which are almost normal levels. 3. Decreasing rate of endothelial cell density in group 1 and 2 showed 20.2% and 22.7% on the post-operative 4th day, 5.3% and 5.2% on the postoperative 28 th day, 2.8% and 2.7% after 3 months and after 5 months 1.5% and 1.3% respectively. 4. The changes in the corneal thickness and loss of endothelial cell density were not significant statistically between group 1 and 2. 5. Light microscopic finding showed mild chronic inflammatory infiltrates in the stroma of iris and ciliary body in both groups. 6. Scanning electron microscopic finding showed normal hexagonal cell shape with some edema in both groups on the postoperative 14th day while both groups showed normal cell shape without edema 28 days, 3 months and 5 months after the operation. 7. Transmission electron microscopic finding showed no changes in internal structure of endothelial cells 14 days, 28 days, 3 months and 5 months after the operation. In conclusion, the implantation in rabbits eyes of the UNI-IOL showed little difference in clinical and histopathologic findings compared with that of IOLAB-IOL and was well tolerated.

MeSH Terms

Anterior Chamber
Cell Shape
Ciliary Body
Edema
Endothelial Cells
Endothelium, Corneal*
Hyphema
Iris
Korea
Lenses, Intraocular
Postoperative Complications
Rabbits
Wounds and Injuries