J Korean Ophthalmol Soc.  1996 Sep;37(9):1570-1575.

The Effects of Mitomycin C on Trabeculectomy

• Hong SJ
• Moon SC
• Yoo KW
• Rho SH

Abstract

Mitomycin C (MMC) is an antimetabolite, antibiotic which prevents the proliferation of fibroblast and fibrosis by inhibition of DNA-dependent RNA synthesis. It has been used to increase the success rate of filtering surgery. We performed trabeculectomy and peripheral iridectomy with 0.4 mg/ml MMC application for 3 minutes in poor prognostic glaucoma patient, 26 eyes of 24 patients from February 1992 to December 1994. The postoperative change of intraocular pressure (IOP) and complications were followed up from 3 to 30 months (mean 12.4 months). The preoperative and postoperative mean IOP after 24 months were 32.3 +/- 11.4 mmHg and 12.7 +/- 3.1 mmHg, respectively. The decrease rate of IOP was 60.7% and the success rate was 71.7%. The postoperative complications were 15 eyes including 5 eyes of shallow anterior chamber, 5 eyes of hyphema, 2 eyes of conjunctival wound leakage, one eye of bleb rupture, one eye of choroidal detachment, and one eye of cataract formation.

Keyword

Intraocular pressure (IOP); Mitomycin C (MMC); Poor prognostic glaucoma; Trabeculectomy

MeSH Terms

Anterior Chamber
Blister
Cataract
Choroid
Fibroblasts
Fibrosis
Filtering Surgery
Glaucoma
Humans
Hyphema
Intraocular Pressure
Iridectomy
Mitomycin*
Postoperative Complications
RNA
Rupture
Trabeculectomy*
Wounds and Injuries
Mitomycin
RNA