J Korean Ophthalmol Soc.  1995 Jun;36(6):915-923.

Trabeculectomy with Mitomycin C(MMC)

• Cho YS
• Choe YJ
• Hong YJ

Abstract

Mitomycin C has an inhibitory effect on the proliferation of fibroblasts and it is used as an adjunct to trabeculectomy. To clarify the effects of mitomycin C on trabeculectomy, we ana lysed 95 eyes that received trabeculectomy with mitomycin C and 90 eyes that received trabeculectomy without mitomycin C. There were no significant differences in sex, age, type of glaucoma and preoperative intraocular pressure (IOP) between two groups (p>0.05 respectively). The mean rops at 6 months after surgery and the success rate were not significantly different between two groups (p>0.05). But considering the mean IOP of successful cases, the mitomycin C used group showed the lower postoperative IOP(p<0.05). The rate of complete seccess which had no antiglaucoma medications and 5-fluorouracil administration during the postoperative period was higher in the mitomycin C used group (p<0.05). Postoperative complications, espicially hypotony, were more common in the mitomycin C used patients. Hypotony was more frequent in the patients who received brief exposure of mitomycin C. Most of the hypotony patients had primary open angle glaucoma and lower preoperative IOP. According to the results of our study, mitomycin C should be used in the high risk group patients who are young and have secondary glaucoma or history of failure of filtering procedures, and also in the patients with difficulty of postoperative medical treatment and requiring lower IOP.

Keyword

Trabeculectomy; Mitomycin C.

MeSH Terms

Fibroblasts
Fluorouracil
Glaucoma
Glaucoma, Open-Angle
Humans
Intraocular Pressure
Mitomycin*
Postoperative Complications
Postoperative Period
Trabeculectomy*
Fluorouracil
Mitomycin