J Korean Ophthalmol Soc.  1996 Apr;37(4):622-627.

Low-dose and High-dose of Mitomycin-C in Trabeculectomy

• Lee JJ
• Park KH
• Youn DH

Abstract

The purpose of this study is to compare the effects of three different concentrations of mitomycin-C(MMC) as an adjunct therapy to trabeculectomy. We reviewed 26 patients(36 eyes) who underwent trabeculectomy in which MMC was applied intraoperatively. The application time was 5 minute, and concentration of MMC was 0.1mg/ml(n=10), 0.2mg/ml(n=17) and 0.41mg/ml(n=9) respectively. The mean IOP at postoperative 3 months was significantly lower in 0.4mg/ml group (10.4 +/- 5.5mmHg) than in the 0.2mg/ml group(16.1 +/- 4.7mmHg)(p<0.05). There was no statistical difference among the three groups in the success rate regardless of medication, the size and longevity of bleb. The postoperative hypotony(2 eyes) was noted in the 0.4mg/ml group. In conclusions, It is desirable to use the lowest concentration of MMC that will facilitate bleb formation.

Keyword

Complete success; Hypotony; Mitomycin-C; Trabeculectomy

MeSH Terms

Blister
Longevity
Mitomycin*
Trabeculectomy*
Mitomycin