J Korean Ophthalmol Soc.  1995 Jul;36(7):1162-1170.

Efficacy of Fluconazole in The Treatment of Candida albicans Keratitis in Rabbits

• Byun KS
• Hahn YH

Abstract

In order to evaluate the effect of fluconazole on Candida albicans induced keratitis, an experimental study was conducted on 30 rabbits. After 4 days of inoculation with Candida albicans on rabbit cornea, animals were divided into three treatment groups: daily treatment with a single oral dose of 50mg fluconazole(group 1); topical therapy with 0.3% fluconazole solution 6 times a day(group 2); control animals without any medical treatment(group 3). The rabbits were treated for 28 days following completion of Candida albicans inoculation, and the severity of keratitis was examined with a slit lamp biomicroscope every two days throughout the treatment period. After the treatment, animals were sacrified and histopathological study of the corneas were per formed. Animals in group 1 and 2 showed significant improvements in keratitis compared to that of control animals beginning 10 days of treatment(p<0.05). No statistically significant difference between the group 1 and group 2 were noted in response to treatment(p>0.05). Thus, we suggest that fluconazole is effective in treatment of keratitis induced by Candida albicans.

Keyword

Candida albicans keratitis; 0.3% Fluconazole solution; Oral fluconazole

MeSH Terms

Animals
Candida albicans*
Candida*
Cornea
Fluconazole*
Keratitis*
Rabbits*
Fluconazole