J Korean Ophthalmol Soc.  1995 Jul;36(7):1162-1170.

Efficacy of Fluconazole in The Treatment of Candida albicans Keratitis in Rabbits

Affiliations
  • 1Department of Ophthalmology, Kosin Medical College, Pusan, Korea.

Abstract

In order to evaluate the effect of fluconazole on Candida albicans induced keratitis, an experimental study was conducted on 30 rabbits. After 4 days of inoculation with Candida albicans on rabbit cornea, animals were divided into three treatment groups: daily treatment with a single oral dose of 50mg fluconazole(group 1); topical therapy with 0.3% fluconazole solution 6 times a day(group 2); control animals without any medical treatment(group 3). The rabbits were treated for 28 days following completion of Candida albicans inoculation, and the severity of keratitis was examined with a slit lamp biomicroscope every two days throughout the treatment period. After the treatment, animals were sacrified and histopathological study of the corneas were per formed. Animals in group 1 and 2 showed significant improvements in keratitis compared to that of control animals beginning 10 days of treatment(p<0.05). No statistically significant difference between the group 1 and group 2 were noted in response to treatment(p>0.05). Thus, we suggest that fluconazole is effective in treatment of keratitis induced by Candida albicans.

Keyword

Candida albicans keratitis; 0.3% Fluconazole solution; Oral fluconazole

MeSH Terms

Animals
Candida albicans*
Candida*
Cornea
Fluconazole*
Keratitis*
Rabbits*
Fluconazole
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