J Korean Ophthalmol Soc.
1988 Aug;29(4):529-533.
The Effect of Ketoconazole in the Treatment of Candida albicans Keratitis in Rabbits
- Affiliations
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- 1Department of Ophthalmology, National Medical Center, Seoul, Korea.
Abstract
- Candida albicans keratitis was established in rabbits by intrastromal injection of a suspension containing 1.2 X 10(4) spores. After a 48-hour incubation period, the animals were treated with oral ketoconazole(10mg/kg daily) alone and in combination with topical ketoconazole(2% solution ten times a day) for 2 weeks. Clinical scores were significantly lower in both treated groups than in the control group. But there was no significant difference between the two treated groups.
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