J Korean Ophthalmol Soc.  1993 May;34(5):468-473.

Study on the Effectivity and Stability of the Fortified Ophthalmic Solutions

• Kim JB
• Jeong SK
• Park YG
• Ryu PY

Abstract

The questions concerning storage temperature and storage duration of the fortified ophthalmic antibiotic solutions are raised. The aim of the current study is to evaluate the influence of fortified ophthalmic antibiotic solutions on its biological and physical properties according to the storage temperature and duration as time goes by. We examined the changes of pH, absorbance spectra, and anti-microbial activity of cefradine(63mg/ml)and gentamicin sulfate(13.6mg/ml) over a four-week period. The results were as follows: There was no difference between the potency of fortified GM solutions stored at 4 degrees C and that at 24 degrees C for 4 weeks. The cefradine stored 24 degrees C exhibited significant changes in both its tJotency and stability after ithe seventh day of storage. The cefradine stored at 4 degrees C exhibited changes in Its absorbance spectra day by day and potency after 14th day.

Keyword

Anti-microbial activity; Duration; Fortified antibiotic solutions; Storage; Temperature

MeSH Terms

Cephradine
Gentamicins
Hydrogen-Ion Concentration
Ophthalmic Solutions*
Cephradine
Gentamicins
Ophthalmic Solutions