J Korean Ophthalmol Soc.
1991 Apr;32(4):289-293.
Rabltit Model of Acenitine Myelo-optic Neuropathy
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- 1Department of Ophthalmology, School of Medicine, Kyung-Pook National University, Taegu, Korea.
Abstract
- A single sublethal dose of aconitine, a principal constituent of aconite, was administered intraperitoneally to evaluate its toxic effects on the visual pathway, spinal cord and peripheral nerve of the rabbit. Histopathological findings indicate that moderate aconitine poisoning in the rabbit consists primarily of myelopathy. Aconitine is chemically acetyl-benzoyl-ester of aconin, a base derived from quinonline. This fact may explain the similarity of pathologic pictures between subacute myelo-optic neuropathy(SMON) caused by halogenated hydroxyquinoline and acomtine poisoning.
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