J Korean Ophthalmol Soc.  1990 Feb;31(2):207-213.

Effect of Carteolol Hydrochloride on Sodium-Potassium Activated ATPase in Cattle Lena Epithelial Cell Membrane

• Lee KH
• Chang WG
• Kang BN

Abstract

The effect of Carteolol hydrocholride on the Na-K ATPase of anterior capsule and epithelium of cattle lens has been investigated. The experiments were also designed to determine the action of Carteolol hydrochloride on the Na-K ATPase activity in anterior capsule and epithelium of cattle lens. The following results were observed. 1. The predominent location of Na-K ATPase was located in the epithelim and NaK ATPase was closely related with active trasport system of sodium and potassium in the lens epithelium. 2. The activity of Na-K ATPase of cattle lens epithelium was alomst totally inhibited by Ouabain. 3. Beta-adrenergic blocking agent(Carteolol hydrochloride) in the epithelium of cattle lens was shown to be actively transported by the ATPase. 4. The Na-K ATPase activity of cattle lens epithelium was inhibited by Carteolol hydrochloride.

Keyword

Active transport; Na-K ATPase; Inorganic phosphate; Carteolol hydrochloride; Cat aract formation

MeSH Terms

Adenosine Triphosphatases*
Animals
Biological Transport, Active
Carteolol*
Cattle*
Epithelial Cells*
Epithelium
Membranes*
Ouabain
Potassium
Sodium
Adenosine Triphosphatases
Carteolol
Ouabain
Potassium
Sodium