J Korean Ophthalmol Soc.  2015 May;56(5):776-779. 10.3341/jkos.2015.56.5.776.

A Case of Eccrine Spiradenoma of the Eyelid

• Ha MJ
• Park JW
• Kim TJ
• Lee KW

• KMID: 2121179
• DOI: http://doi.org/10.3341/jkos.2015.56.5.776

Abstract

PURPOSE
To report a case of eccrine spiradenoma that presented as an eyelid nodule.
CASE SUMMARY
A 61-year-old female presented with a mass in the right upper lid margin; the onset time was unknown. An ophthalmic examination revealed no abnormalities except the eyelid nodule. The nodule was 3 mm in size with a firm, smooth surface and light pinkish color, and was located near the lid margin. Excision and biopsy of the nodule was performed. The pathological findings of the specimen obtained showed islands of 2 types of lobular cells. Larger, paler cells were grouped around the central area, darker and smaller cells on the periphery. These findings were compatible with eccrine spiradenoma.
CONCLUSIONS
Eccrine spiradenoma should be considered a differential diagnosis of a solitary eyelid tumor.

Keyword

Eccrine spiradenoma; Eyelid mass

MeSH Terms

Biopsy
Diagnosis, Differential
Eyelids*
Female
Humans
Islands
Middle Aged

Figure

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  Figure 1. Pinkish and solitary nodule of smooth-surface on the margin of the right upper eyelid.

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  Figure 2. Sharply circumscribed and encapsulated tumor nodule arising within the dermis. The tumor is comprised of a dif-fuse densebasaloidcellular proliferation (H&E, ×40).

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  Figure 3. Two distinct populations of neoplastic epithelial cells can be seen, dark and pale. Dark cells are small, basaloid cells with hyperchromatic nuclei located at the periphery, whereas pale cells, which are larger with vesicular nuclei and ample pale cytoplasm, tend to be near the centre of the clusters (H&E, ×100).

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  Figure 4. (A) The tumor cells were positive for Periodic Acid-Schiff immunostaining (Immunohistochemical stain for the selected proteins, x400). (B) The tumor cells were positive for Cytokeratin AE1/AE3 immunostaining (Immunohistochemical stain for the selected proteins, ×200). AE = anti-cytokeratin antibody.

Reference

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