Ann Dermatol.  2011 Oct;23(Suppl 2):S197-S200. 10.5021/ad.2011.23.S2.S197.

Giant Vascular Eccrine Spiradenoma

• Kim MH
• Cho E
• Lee JD
• Cho SH

• KMID: 2156788
• DOI: http://doi.org/10.5021/ad.2011.23.S2.S197

Abstract

Giant vascular eccrine spiradenomas (GVESs) are a rare variant of the eccrine spiradenoma that develops from the sweat gland. It is different from the eccrine spiradenoma in its larger size and greater degree of vascularity. Bleeding and/or ulceration are common clinical features of this tumor, and are the reason why it is often clinically confused with a vascular or malignant tumor. Here, a rare case of GVES without bleeding or ulceration is reported.

Keyword

Eccrine spiradenoma; Giant vascular eccrine spiradenoma; Sweat gland neoplasms

MeSH Terms

Hemorrhage
Sweat Gland Neoplasms
Sweat Glands
Ulcer

Figure

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  Fig. 1 A solitary, bluish, 2.5×2.5 cm, firm deep mass (arrow) on the right upper arm.

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  Fig. 2 (A) Well-demarcated, encapsulated, multilobulated tumor in the dermis with many blood-filled vessels and extensive hemorrhage (H&E, ×25). (B) The tumor was composed of two types of cells: cells with small, dark nuclei at the periphery of the lobules and cells with large, pale nuclei in the center of the lobules (H&E, ×200).

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  Fig. 3 Immunohistochemical staining for CK (A: ×100), EMA (B: ×100), S-100 (C: ×100), SMA (D: ×100), and p63 (E: ×100). CK: cytokeratin, EMA: epithelial membrane antigen, SMA: smooth muscle actin.

Reference

1. Cotton DW, Slater DN, Rooney N, Goepel JR, Mills PM. Giant vascular eccrine spiradenomas: a report of two cases with histology, immunohistology and electron microscopy. Histopathology. 1986. 10:1093–1099.

2. Taylor RS, Perone JB, Kaddu S, Kerl H. Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, editors. Appendage tumors and hamartomas of the skin. Fitzpatrick's dermatology in general medicine. 2008. 7th ed. New York: McGraw-Hill;1068–1087.

3. Ahmed TS, Priore JD, Seykora JT. Elder DE, Elenitsas R, Johnson BL, Murphy GF, Xu X, editors. Tumors of the epidermal appendages. Lever's histopathology of the skin. 2009. 10th ed. Philadelphia: Lippincott Williams & Wilkins;851–909.

4. Hey A, Grouls V, Röckelein G. Vascular eccrine giant spiradenoma--a case report with histology and immunohistology of a rare variant of benign sweat gland tumors. Z Hautkr. 1988. 63:444–447.

5. Senol M, Ozcan A, Sasmaz S, Ozen S, Ciralik H. Giant vascular eccrine spiradenoma. Int J Dermatol. 1998. 37:221–223.

6. Ko JY, Lee CW, Moon SH, Song KW, Park CK. Giant vascular eccrine spiradenoma: report of a case with immunohistochemical study. J Korean Med Sci. 2006. 21:172–176.

7. Yamakoshi T, Makino T, Watanabe H, Furuichi M, Matsui K, Shimizu T. A case of giant vascular eccrine spiradenoma with unusual clinical features. Clin Exp Dermatol. 2009. 34:e250–e251.

8. Eckert F, Betke M, Schmoeckel C, Neuweiler J, Schmid U. Myoepithelial differentiation in benign sweat gland tumors. Demonstrated by a monoclonal antibody to alpha-smooth muscle actin. J Cutan Pathol. 1992. 19:294–301.

9. Wiley EL, Milchgrub S, Freeman RG, Kim ES. Sweat gland adenomas: immunohistochemical study with emphasis on myoepithelial differentiation. J Cutan Pathol. 1993. 20:337–343.

10. Meybehm M, Fischer HP. Spiradenoma and dermal cylindroma: comparative immunohistochemical analysis and histogenetic considerations. Am J Dermatopathol. 1997. 19:154–161.

11. McCalmont TH. A call for logic in the classification of adnexal neoplasms. Am J Dermatopathol. 1996. 18:103–109.