Experimental Assessment of the Histologic Changes of Collagen Matrix(Terudermis(R)) in Subcutaneous Implantation: Comparison with Autologous Dermal Graft

Kim, Boo Yeong; Kang, So Ra; Lee, Ji Hyuck; Burm, Jin Sik; Kim, Yang Woo; Lee, Min Jin; Kang, Won Kyung

Abstract

PURPOSE
Numerous materials, both autologous and nonautologous, have been used for augmentation of sunken areas, but they have their own limitations. The purpose of this study is to determine the histologic response and volume change of the xenogenic collagen-based scaffold(Terudermis(R)) to the transfer into a subcutaneous soft tissue location in vivo rabbit model.
METHODS
Eighteen New Zealand white rabbits were used. Three 1.2x1.2cm sized subcutaneous pockets were created on the dorsal surface of each ear. 1x1 cm sized collagen matrix(Terudermis(R)) and autologous dermal graft were implanted into each pocket. Full thickness of ear was harvested in 3 days, 1, 2, 4 weeks, 3, 6 months after implantation.
RESULTS
Histological analysis of implants demonstrated progressive neovascularization, fibroblast infilteration, neocollagen bundle synthesis and organization, and few foreign body reaction. The thickness of the collagen matrix in 3 days after the operation was 87.69% of the thickness of the collagen matrix in wet state. Then it decreased to 30.17% in 6 months after the operation. The rate of decrease was similar at all points at the same time compared with autologous dermal graft.
CONCLUSION
Our experimental study suggests that Terudermis(R) could be a safe material as an implant for permanent augmentation in subcutaneous tissue. However the choice of graft for augmentation should be remained to the clinical situations.