J Korean Radiol Soc.  1994 Oct;31(4):667-672.

Silicone Covered vs. Non-covered Endotracheal Self-expandable Metallic Stent: An Experimental Study

• Do YS
• Lee BH
• Kim KH
• Cho DS
• Chin SY
• Kim SA
• Cho KJ

Abstract

PURPOSE
To evaluate pathologic changes of the trachea and the lung after insertion of silicone covered and non-covered Gianturco stent in the trachea of dog.
MATERIALS AND METHODS
Silicone covered(covered) and non-covered(bare) Gianturco stents, six in each, were inserted into the tracheal lumen of six consecutive dogs. After 1--10 week observation, the dogs were sacrificed and their tracheas and lungs were examined grossly and histopathologically. Serial chest radiographs were performed to evaluate pneumonia and stent migration every 3--5 days.
RESULTS
Pneumonia was observed in one of bare stent group and five of covered stent group. Stent migration was noted in three of covered stent group. In bare stent group, the epithelium of the trachea was markedly thickened by hyperplasia and stent was covered by granulation tissue from 6 weeks after stent insertion. Inflammation was focal at contact site between the stent and the trachea. In covered stent group, the epithelium was denuded at multiple areas and there were multifocal squamous metaplasia of the mucosa. Inflammatory reaction of the trachea was diffuse.
CONCLUSION
Inflammatory reaction was more severe and stent migration was more frequent in covered stent group. The use of covered stent in the trachea should be studied further.

MeSH Terms

Animals
Dogs
Epithelium
Granulation Tissue
Hyperplasia
Inflammation
Lung
Metaplasia
Mucous Membrane
Pneumonia
Radiography, Thoracic
Silicones*
Stents*
Trachea
Silicones