Korean J Urol.  1994 Sep;35(9):944-948.

Histological Changes in Ileal Reservoir Mucosa after Long-term Exposure to Urine

Affiliations
  • 1Department of Urology, College of Medicine, Ewha Woman University, Seoul, Korea.

Abstract

Mucosal biopsies were obtained for histological and electron microscopical studies from 7 patients with ileal urinary conduit. Shortly after construction of the reservoir there was a reduction in villous height and an increase in crypt depth. After 2 to 3 years of observation, avillous areas were noted in the reservoir mucosa. Electron microscopy shows a loss of microvilli and a reduction of cell construction. The number of mucus-storing goblet cells increased already with in 1 month after construction. No sign of foreign body reaction, dysplasia or metaplasia was encountered. The constant exposure to urine leads to adaptive changes of the reservoir mucosa, resulting in true atropy of villi, crypts, and individual epithelial cells.

Keyword

Ileal conduit; Intestinal mucosa; Histological alterations

MeSH Terms

Biopsy
Colonic Pouches*
Epithelial Cells
Foreign-Body Reaction
Goblet Cells
Humans
Intestinal Mucosa
Metaplasia
Microscopy, Electron
Microvilli
Mucous Membrane*
Pheniramine
Urinary Diversion
Pheniramine
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