J Korean Ophthalmol Soc.
2002 Mar;43(3):608-614.
Apoptosis in Experimental Autoimmune Uveitis
- Affiliations
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- 1Department of Ophthalmology, Seoul National University, College of Medicine, Korea.
- 2Seoul Artificial Eye Center Clinical Research Institute Seoul National University Hospital, Korea. chungh@snu.ac.kr
- 3Department of Anatomy, Seoul National University College of Medicine, Korea.
- 4Department of Anatomy, Dankook University College of Medicine, Korea.
Abstract
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PURPOSE: Fas ligand is known to play a key role in intraocular inflammation. We investigated the change of the expression of Fas ligand in the eye with experimental melanin-induced uveitis (EMIU).
METHODS
EMIU was induced in 16 Lewis rats after immunization with melanin-associated antigen. Immunohistochemistry, in situ hybridization, and Western blot for Fas ligand were performed serially after immunization.
RESULTS
The expression of Fas ligand was higher in the inflammatory eyes at cornea, iris, ciliary body, choroids and retina compared with control eyes. The expression of FasL remained elevated ever at 30 days after immunization in comparison with control eyes even though the inflammation of the eyes had subsided.
CONCLUSIONS
These results suggest that the spontaneous regression of intraocular inflammation may be mediated by Fas ligand in EMIU.
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