J Korean Ophthalmol Soc.  1990 Jun;31(6):767-771.

Effect of Epinephrine or Pilocarpine on me Ocular Blood Flow

• Lee KW

Abstract

The ocular vascular resistance of the ciliary choroidal network has been investigated on measurements of pulse amplitude(PA). The ocular pulse is derived from the ciliary choroidal blood flow which account for more than 90% of the total ocular blood flow(OBF). In 5 normal Cynomolgus monkeys with topical application(50 micro l) of 2% epinephrine, the PA revealed a significant reduction(0.32 +/- 0.06mmHg, mean +/- SEM, p<0.01). In the other 5 normal Cynormlgus monkeys with 4% pilocarpine, the PA revealed no significant increment(0.32 +/- 0.15mmHg, mean +/- SEM, p<0.10) by the OBF system. These results suggest that topical application of epinephrine produces a significant reduction of OBR but pilocarpine produces a mild increment of OBF.

Keyword

Epinephrine; Ocular blood flow(OBF) Ocular pulse amplitude(PA); Ocular vas cular resistance; Pilocarpine

MeSH Terms

Choroid
Epinephrine*
Haplorhini
Macaca fascicularis
Pilocarpine*
Vascular Resistance
Epinephrine
Pilocarpine