J Korean Ophthalmol Soc.  1970 Dec;11(4):17-21.

Effects of Ascorbic acid on the Intraocular Pressure and Serum Osmolarity in Rabbits

• Moon HJ

Abstract

Changes in the intraoular pressure and serum osmolarity were investigated in albino rabbits after intravenous and topical administrations of ascorbic acid. Twenty percent solution of ascorbic acid administered intravenously produced reduction in intraocular pressure from 24.3 mmHg. to 14.0 mmHg. in 10 minutes. The lowering was maintained for 30 minutes followed by low recovery. The serum osmolarity rose from 285.1 mOsm. to 302.0 mOsm. in 10 minutes, and returned gradually thereafter. Intravenous injection of 10 % ascorbic acid brought about milder drop in intraocular pressure, from 21.7 mmHg. to 16. 9 mmHg and more rapid recovery. The serum osmolarity rose from 282.0 mOsm. to 290 mOsm and returned to the original level. No significant changes in the intraocular pressure were observed after the instillation of 10 % ascorbic acid solution.

MeSH Terms

Administration, Topical
Ascorbic Acid*
Injections, Intravenous
Intraocular Pressure*
Osmolar Concentration*
Rabbits*
Ascorbic Acid