J Korean Orthop Assoc.
2001 Feb;36(1):9-16.
Mutations of the p53 tumor suppressor gene in rheumatoid arthritis synovium
- Affiliations
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- 1Department of Orthopaedic Surgery, Taejon St. Mary's Hospital, University of Catholic, Korea.
- 2Department of Orthopaedic Surgery, Our lady of Mercy Hospital, University of Catholic, Korea.
- 3Department of Orthopaedic Surgery, Kang Nam St. Mary's Hospital, University of Catholic, Korea.
Abstract
- PURPOSE
To analyse the expression of the p53 tumour suppressor gene in the synovial tissue from rheumatoid patients. Material and Methods : Synovial membranes were obtained from 13 patients diagnosed as having RA, and 9 osteoarthritis (OA) patients. We studied p53 expression by immunohistochemical analysis and p53 DNA sequence using direct DNA preparation method. RESULT: In immunohistological studies, the Do-1 monoclonal antibody stained at 6 specimens out of the 13 rheumatoid arthritis tissue biopsies analysed. There was no p53 mutation in osteoarthritis samples, but there were 4 p53 mutations from the 13 rheumatoid arthritis samples. p53 mutations were found at the codon 177 (CTG to CTA, GA), 277 (TGT to TGC, TC), and, two patients at the codon 237 (CAT to TAT, CT).
CONCLUSION
The predicted amino acid substitutions in p53 were similar to those commonly observed in a variety of tumors and might influence growth and survival of rheumatoid synoviocytes.
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