- The Immunohistochemical Study of Oncogene and Tumor Suppressor Gene Proteins on Bone Tumor
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Kim MK, Yeom BW, Lee JH
- KMID: 2105099
- J Korean Orthop Assoc.
- 1997 Jun;32(3):623-631.
The discovery of oncogenes and tumor suppressor genes have made it possible to partly understand the mechanism of cancer development. It is generally accepted that the cancer development is caused... -
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- Loss of PTEN Expression in Primary Lung Cancer
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Roh MS
- KMID: 2275559
- Korean J Pathol.
- 2002 Oct;36(5):286-291.
BACKGROUND: The phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene, a candidate tumor suppressor, is localized to chromosome 10q23 and shares extensive homology with cytoskeletal proteins auxilin and... -
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- Annotation of Genes Having Candidate Somatic Mutations in Acute Myeloid Leukemia with Whole-Exome Sequencing Using Concept Lattice Analysis
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Lee KH, Lim JH, Kim JH
- KMID: 1806269
- Genomics Inform.
- 2013 Mar;11(1):38-45.
- doi: 10.5808/GI.2013.11.1.38
In cancer genome studies, the annotation of newly detected oncogene/tumor suppressor gene candidates is a challenging process. We propose using concept lattice analysis for the annotation and interpretation of genes... -
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- p53 Gene Mutations in Transitional Cell Carcinoma of the Renal Pelvis
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Uhm SY, Kong G, Park HY
- KMID: 1764378
- Korean J Urol.
- 1997 Apr;38(4):368-377.
Inactivation or loss of suppressor genes on a specific chromosome plays an important role in the development and progression of cancer. Recent studies have shown that p53 gene acts as... -
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- Loss of Heterozygosity on Chromosome 10, 13, 17 and p53 Gene Mutations in Human Brain Gliomas
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Lee SH, Kim JH, Rhee CH, Kang YS, Lee JH, Choi KS
- KMID: 2187842
- J Korean Neurosurg Soc.
- 1993 Apr;22(4):537-550.
Gliomas, the most common primary tumors of the human central nervous system, are usually malignant and virtually incurable. They can be classified according to their cellular differentiation:astrocytoma, oligodendroglioma, and ependymoma.... -
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- Mutational Research of von Hippel-Lindau Gene of Family with von Hippel-Lindau Disease
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Eom KS, Kim TY, Kim JM
- KMID: 1955776
- J Korean Neurosurg Soc.
- 2003 Sep;34(3):197-201.
OBJECTIVE: The von Hippel-Lindau (VHL) disease is an autosomal dominant disorder caused by deletions or mutations in a tumor suppressor gene on human chromosome 3p25. We investigate the VHL germline... -
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- Role of the nm23-H1 gene in the metastasis of gastric cancer
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Hwang BG, Park IC, Park MJ, Moon NM, Choi DW, Hong WS, Lee SH, Hong SI
- KMID: 645111
- J Korean Med Sci.
- 1997 Dec;12(6):514-518.
- doi: 10.3346/jkms.1997.12.6.514
The nm23 gene is now generally accepted as one of the suppressor genes for metastasis in many types of human cancer. To investigate the role of the nm23 gene... -
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- Mutations of the p53 tumor suppressor gene in rheumatoid arthritis synovium
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Han CW, Kim HK, Kim WY, Lee KW, Ohm EY, Kim JM
- KMID: 2105712
- J Korean Orthop Assoc.
- 2001 Feb;36(1):9-16.
PURPOSE: To analyse the expression of the p53 tumour suppressor gene in the synovial tissue from rheumatoid patients. Material and Methods : Synovial membranes were obtained from 13 patients diagnosed... -
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- A Clinical Analysis of Methylation Status of Tumor Suppressor Genes in Breast Cancer
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Jung H, An CH, Kim KH, Kim JI, Park WC, Song BJ, Jung SS, Lim KW, Kim JS
- KMID: 2210309
- J Korean Surg Soc.
- 2006 Apr;70(4):253-264.
PURPOSE: Aberrant methylation of CpG islands in gene promoters has been considered as a common mechanism for suppressing gene expression in cells. Hypermethylation of CpG islands in promoters is associated... -
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- Gene Expression in Gastric Adenocarcinomas
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Lee JH, Choi SR, Han SY, Hwang TH, Kim MC, Jung GJ, Roh MS, Jeong JS
- KMID: 2184629
- J Korean Gastric Cancer Assoc.
- 2002 Dec;2(4):213-220.
PURPOSE: The cDNA microarray provides a powerful alternative with an unprecedented view in monitoring gene- expression levels and leads to discoveries of regulatory pathways involved in complicated biological processes. Our... -
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- Loss of heterozygosity on chromosome XP22.2-p22.13 and Xq26.1-q27.1 in human breast carcinomas
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Choi C, Kim MH, Juhng SW
- KMID: 1745556
- J Korean Med Sci.
- 1998 Jun;13(3):311-316.
- doi: 10.3346/jkms.1998.13.3.311
In an attempt to investigate the X chromosome harboring putative tumor suppressor genes (TSGs) in sporadic breast carcinoma, we performed loss of heterozygosity (LOH) studies on 23 breast carcinomas... -
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- The Expression of p53, c-erbB-2 and nm23 Proteins in Breast Cancer
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Lee KY, Kim YG, Kim YS, Han KJ, Kang CS, Kim JA, Kim WI, Shim SI
- KMID: 1921777
- Korean J Pathol.
- 1999 Feb;33(2):88-95.
Recently, p53, c-erbB-2 and nm23 proteins have been studied in breast cancer. The expression of p53 protein indicates the mutation of p53 gene known as a tumor supressor gene, and... -
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- nm23 Protein Immunohistochemical Expression in Colorectal Carcinoma and its Relationship with Other Prognostic Factors
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Lee SN, Koo H, Han WS
- KMID: 2141051
- Korean J Pathol.
- 1998 Jun;32(6):413-419.
The purpose of this study was to determine the immunohistochemical expression of nm23-H1, a putative metastatic suppressor gene, and to correlate its expression with clinicopathologic variables in 75 cases of... -
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- p53 Suppressor Gene Ove rex p ression in the Cornea after Mechanical-and Chemical-induced Epithelial Injury
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Ko CH, Lee DH, Joo MJ
- KMID: 2205549
- J Korean Ophthalmol Soc.
- 1999 Sep;40(9):2378-2384.
p53 suppressor gene expression and protein production increases in response to DNA damage and the subsequent cell cycle prolongation permits DNA repair or, in the severe cases, leads to apoptosis.... -
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- The Value of the Expression of bel-2 and p53 in Colorectal Carcinomas
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Chang JH, Clung KH, Kim KC, Kim CY
- KMID: 1944911
- J Korean Soc Coloproctol.
- 1997 Mar;13(1):31-42.
There are a lots of evidences that colorectal cancer arise as a result of multiple alterations of genes. Many attempts were made to understand the role of oncogenes and suppressor... -
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- Prognostic Implication of p53 Immunohistochemical Staining in Patients with Localized Renal Cell Carcinoma after Radical Nephrectomy
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Lee SJ, Kim DK, Lee CH, Chang SG, Kim JI, Kim YW
- KMID: 2289960
- Korean J Urol.
- 1999 Mar;40(3):297-302.
PURPOSE: p53 gene is a well-known suppressor gene of tumor. And the p53 protein expression in immunohistochemical staining acts a role as a prognostic indicator in prostate and bladder tumor.... -
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- Significance of K-ras Mutation and p53 Protein Expression in Pancreatic Adenocarcinoma
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Kim YC, Choi KH
- KMID: 2145297
- J Korean Surg Soc.
- 2000 Feb;58(2):271-279.
BACKGROUND: Activation of the K-ras oncogene by specific point mutations at codon 12 occurs at a remarkably high frequency in pancreatic adenocarcinomas. Also, inactivation of the p53 suppressor gene function... -
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- Molecular Genetic Study on Human Meningiomas:Loss of Heterozygosity on Chromosome 22
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Kim JH, Lee SH, Park SY, Lee JH
- KMID: 2138513
- J Korean Neurosurg Soc.
- 1991 Apr;20(4):193-198.
With the methods of restriction fragment length polymorphisms(RFLPs) and Southern blot, we performed a molecular genetic study in 20 cases of intracranial meningiomas. There were four cases of invasive meningiomas,... -
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- Role of DCC(Deleted in Colorectal Cancer) Gene in Oral Squamous Cell Carcinoma
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Ko SK, Han SJ, Kim KW
- KMID: 2005383
- J Korean Assoc Oral Maxillofac Surg.
- 2008 Oct;34(5):518-524.
Chromosome 18q alteration plays a key role in colorectal tumorigenesis, and loss of heterozygosity at 18q is associated with a poor prognosis in colon cancer. DCC(Deleted in Colorectal Cancer) is... -
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- Comparison of PCR-RFLP and Real-Time PCR for Allelotyping of Single Nucleotide Polymorphisms of RRM1, a Lung Cancer Suppressor Gene
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Jeong JY, Kim MR, Son JG, Jung JP, Oh IJ, Kim KS, Kim YC
- KMID: 2318944
- Tuberc Respir Dis.
- 2007 May;62(5):406-416.
BACKGROUND: Single nucleotide polymorphisms (SNPs), which consist of a substitution of a single nucleotide pair, are the most abundant form of genetic variations occurring with a frequency of approximately 1... -
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