J Korean Radiol Soc.  1998 Feb;38(2):319-327. 10.3348/jkrs.1998.38.2.319.

Gd-DTPA Enhanced Dynamic Renal MR Imaging of Experimentally

• Yang I
• Chung SY
• Lee Y
• Lee KW
• Won MS
• Lee ES
• Lee KS
• Noh JW
• Chun RW
• Kim HT
• Park MH

• KMID: 2103094
• DOI: http://doi.org/10.3348/jkrs.1998.38.2.319

Abstract

PURPOSE: The purpose of this study was to evaluate the utility of Gd-DTPA-enhanced dynamic MRI (DMRI) in earlydiagnosis and the assessment of disease processing in experimentally-induced crescentic glomerulonephritis (CGN)in rabbits.
MATERIALS AND METHODS
In six rabbits, CGN was induced by an injection of anti-glomerular basementmembrane Ab. A time-signal intensity curve (TSC) was obtained from DMRI on the day before, and at 1, 4, 7, 15, 45and 113 days after the induction of CGN. Sequential renal biopsies and blood sampling (serum creatinine) wereperformed on the same days, and the results of DMRI and TSC, were compared.
RESULTS
In normal kidneys, sequentialDMRI demonstrated the intratubular passage of Gd-DTPA as an inwardly migrating, thin, dark, band pattern. On days1 and 4, the thin dark band appeared but was poorly defined and TSC revealed a delay in peak time. On days 7 and15, movement of the band was seen to be weak and slow, and there was no centripetal migration. The maximal signalintensity of TSC was delayed, and the curves declined very slowly. On days 45 and 113, the dark band pattern wasvery weak and slow, and again there was no centripetal migration.
CONCLUSION
GD-DTPA-enhanced DMRI may be ofvalue in the evaluation of disease processing and the severity of CGN.

Keyword

Animals; Kidney, MR; Nephritis

MeSH Terms

Animals
Biopsy
Gadolinium DTPA*
Glomerulonephritis
Kidney
Magnetic Resonance Imaging*
Nephritis
Rabbits
Gadolinium DTPA