J Korean Radiol Soc.  1995 Jul;33(1):7-14.

MR Findings of Congenital Craniocerebral Anomaly: Correlation with Seizures and Developmental Delay

• Kang HK
• Seo JJ
• Chung HD
• Kim YH
• Ko SW
• Yoon JH
• Kirn HJ
• Kim HK

Abstract

PURPOSE
To evaluate characteristic MR findings of craniocerebral anomaly and its relationship with neurologic manifestations.
MATERIALS AND METHODS
We retrospectively reviewed MR images of 36 patients with craniocerebral anomaly diagnosed by MRI and clinical courses. We correlated the characteristic MR findings in 41 lesions with neurologic manifestastions focusing on seizures and developmental delay.
RESULTS
Twenty-three patients with seizures consisted of 14 patients(60%) with neuronal migration disorders and seven(30%) with phakomatosis, among which 18 patients(78%) had generalized type of seizures. Locations of the lesions were the parietal lobes in 11 patients(52%) and the subependymal or periventricular regions in seven(33%). Two patients with tuberous sclerosis had the lesions in both parietal and subependymal areas. Nine patients had the signs of developmental delay that were seen in the four(44%) with schizencephaly, two (22%) with tuberous sclerosis, two(22%) with heterotopia, and one(ll %) with pachygyria.
CONCLUSION
Neuronal migration anomaly was relatively common lesion that presented neurologic manifestations such as seizures and developmental delay. Generalized type of seizures was common. We were able to diagnose these anomalies using the MRI that helped establish therapeutic plans.

MeSH Terms

Humans
Lissencephaly
Magnetic Resonance Imaging
Malformations of Cortical Development
Neurocutaneous Syndromes
Neurologic Manifestations
Neuronal Migration Disorders
Neurons
Parietal Lobe
Rabeprazole
Retrospective Studies
Seizures*
Tuberous Sclerosis