Korean J Dermatol.  2011 Aug;49(8):753-756.

Multiple Congenital Melanocytic Nevi Associated with Developmental Delay

• Kwon SH
• Na SJ
• Yeom KB
• Huh SY
• Na JI

Abstract

Multiple congenital melanocytic nevi (MCMN), defined as the distribution of more than three small- or medium- sized congenital melanocytic nevi (CMN) on the body without a giant CMN, is a rare disease comprising about 4% of patients with CMN. Because MCMN accompanies neurodevelopmental delay, including seizures in 25% of patients as well as the risk of malignant melanoma, it must be carefully followed-up. We report a case of MCMN with developmental delay in a 19-month-old Korean boy. He had a history of febrile seizure when he was 18 months old. He showed a speech delay after the 1-year-follow up, even though there was no evidence of neurocutaneous melanosis (NCM) on brain magnetic resonance imaging (MRI) at the first visit. As MRI has a low sensitivity for detecting NCM in patients with MCMN older than 4-months, close neurodevelopmental assessments should be considered to provide a chance for early rehabilitation.

Keyword

Magnetic resonance imaging; Multiple congenital melanocytic nevi; Neurocutaneous melanosis; Neurodevelopmental assessment; Neurodevelopmental delay

MeSH Terms

Brain
Humans
Infant
Language Development Disorders
Magnetic Resonance Imaging
Melanoma
Melanosis
Neurocutaneous Syndromes
Nevus, Pigmented
Rare Diseases
Seizures
Seizures, Febrile
Melanosis
Neurocutaneous Syndromes