J Korean Soc Coloproctol.  2009 Feb;25(1):1-7. 10.3393/jksc.2009.25.1.1.

The Relatioships Between Tumor-related Gene Expression and Tumor Budding, Tumor Nodule and Lymph Node Extracapsular Extension in Colorectal Cancer

• Kang HJ
• Cho HJ
• Kang GC
• Kim KH
• Kang WK
• Kim JI
• Park JK
• Oh S
• Kim JS
• An CH

• KMID: 2101465
• DOI: http://doi.org/10.3393/jksc.2009.25.1.1

Abstract

PURPOSE: Despite the similar lymph node metastasis observed in patients with advanced colorectal cancer (CRC), there was a different clinical outcome. The relationships between tumor-related gene expression and prognostic factors such as tumor budding, tumor nodule and extracapsular extension (ECE) of lymph nodes in patients with CRC remain unclear yet. The purpose of this study was to evaluate the relationship between expression of molecular markers such as vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), matrix metalloproteinases (MMPs) and E-cadherin and the tumor budding, tumor nodule and ECE of lymph nodes in patients with stage III CRC.
METHODS
The tissue of 87 patients with stage III CRC were investigated for expressions of molecular markers using immunohistochemical methods.
RESULTS
VEGF and MMP-9 expression in tumor tissue were positively associated with the colorectal cancer prognostic factors such as tumor budding, tumor nodule and extracapsular lymph node extension (P<0.05). But, MMP-2, EGF and E-cadherin expression were of no value with regard to them.
CONCLUSION
Our results suggest that molecular markers, in particular VEGF and MMP-9, may provide additional prognostic information regarding tumor budding, ECE and tumor nodule.

Keyword

Colorectal cancer; Prognostic factors; VEGF; MMP-9

MeSH Terms

Cadherins
Colorectal Neoplasms
Epidermal Growth Factor
Gene Expression
Humans
Lymph Nodes
Matrix Metalloproteinases
Neoplasm Metastasis
Vascular Endothelial Growth Factor A
Cadherins
Epidermal Growth Factor
Matrix Metalloproteinases
Vascular Endothelial Growth Factor A