J Korean Soc Neonatol.  2008 May;15(1):38-43.

Correlation of Cord Serum Adiponectin and IGF-I with Fetal Growth in Healthy Term Neonates

• Kim JY
• Cho SJ
• Kim HS
• Park HS
• Park EA

Abstract

PURPOSE: The purpose of this study was to evaluate the relationship between cord serum adiponectin (APN) and IGF-I concentrations and fetal growth.
METHODS
Umbilical cord serum APN and IGF-I concentrations were measured in healthy term singleton deliveries (n=72). The association of cord serum APN and IGF-I concentrations was evaluated in relation to birth weight, height, head circumference, gender, ponderal index, placental weight, feto-placental (F/P) weight ratio, maternal weight gain, and maternal body mass index (BMI).
RESULTS
The mean cord serum APN was 29.2+/-10.46 microgram/mL. The cord serum APN and birth weight demonstrated a bell-shape relationship. The cord serum APN concentration was higher in females than males (P=0.001). The cord serum APN was negatively correlated with maternal BMI (r=-0.301, P=0.027), but the mean cord serum APN concentration was not correlated with birth height, birth head circumference, ponderal index, placental weight, F/P ratio, or maternal weight gain. The mean cord serum concentrations of IGF-I was 51.26+/-21.54 ng/mL. The cord serum IGF-I concentration was positively correlated with birth weight (r=0.312, P=0.009), but not birth height, ponderal index, placental weight, F/P weight ratio, or maternal BMI.
CONCLUSION
APN demonstrated a bell-shaped relationship with birth weight in healthy term infants. IGF-I was highly correlated with fetal growth, especially birth weight.

Keyword

Adiponectin; Insulin like growth factor-I; Fetal growth

MeSH Terms

Adiponectin
Birth Weight
Body Mass Index
Female
Fetal Development
Head
Humans
Infant
Infant, Newborn
Insulin-Like Growth Factor I
Male
Parturition
Umbilical Cord
Weight Gain
Adiponectin
Insulin-Like Growth Factor I