J Korean Soc Neonatol.  2006 Nov;13(2):233-243.

Perinatal Outcome in Preterm Infants with Abnormal Umbilical Artery Doppler Results : Emphasizing on Early Onset Thrombocytopenia and its Risk Factors

• Joung KE
• Shin SH
• Kim JR
• Kim ES
• Kim SD
• Kim DH
• Shim SY
• Kim EK
• Kim HS
• Kim BI
• Choi JH

Abstract

PURPOSE
Umbilical artery Doppler study is a commonly used non-invasive tool in high risk pregnancies because of its good correlation with the degree of placental insufficiency. We analyzed hematologic profiles and perinatal outcome of preterm infants with abnormal umbilical artery Doppler results and the risk factors of early onset thrombocytopenia.
METHODS
We retrospectively reviewed the medical records of preterm infants under 35 weeks of gestational age at birth who were admitted to the neonatal intensive care unit of Seoul National University Children's Hospital from January 1, 2002 through December 31, 2004, and whose mothers had undergone umbilical artery Doppler studies within 5 days before delivery. Sixty two neonates were divided into three groups; the 1st group was defined as the patients with normal umbilical artery (UA) systolic/diastolic (S/D) ratio, the 2nd group, with increased UA S/D ratio above 95 percentile, and the 3rd, with absent or reversed end-diastolic flow (AREDF).
RESULTS
Mean nucleated red blood cell (nRBC) counts per 100 white blood cells (WBCs) were 14.2 (0-150), 91.0 (0-262), 301.4 (6-884) (P<0.001), mean WBC counts were 10.8 (0- 34.1), 9.2(3.4-23.9), 5.9(0.5-15.2) (x1,000/mm(3)) (P=0.007), and mean platelet counts were 215.5+/-69.2, 185.9+/-96.7, 100.2+/-50.3 (x1,000/mL) (CONCLUSION
Preterm neonates with abnormal umbilical artery Doppler results had higher nRBC, lower WBC and platelet counts. Lower gestational age and AREDF were risk factors of early onset thrombocytopenia.

Keyword

Umbilcal artery Doppler; Placental insufficiency; Preterm neonates; Hematologic profile; Nucleated red blood cell; Platelet; Early onset thrombocytopenia

MeSH Terms

Arteries
Blood Platelets
Erythrocytes
Gestational Age
Humans
Infant, Newborn
Infant, Premature*
Intensive Care, Neonatal
Length of Stay
Leukocytes
Medical Records
Mothers
Parturition
Placental Insufficiency
Platelet Count
Pregnancy
Retrospective Studies
Risk Factors*
Seoul
Thrombocytopenia*
Umbilical Arteries*