J Korean Soc Neonatol.
1999 Nov;6(2):276-279.
A Case of Alloimmune Neonatal Neutropenia
- Affiliations
-
- 1Department of Pediatrics, Pohang St. Mary's Hospital, Pohang, Korea.
Abstract
- Alloimmune neonatal neutropenia (ANN) is due to maternal IgG neutrophil-specific antibodies that cross the placenta to sensitize fetal neutrophils and cause neutropenia in the neonate. Infection appears within a few days of life. Neutropenia worsens during the very first days of life and persists until 20-50 days in spite of the disappearance of detectable antibody in the infant's serum. We report a case of ANN in female neonate who was admitted on the 5th day of life due to poor oral intake. The diagnosis was made by indirect immunofluorescence with fluorescein-tagged antihuman globulin reagent. The patient was treated successfully with systematic intravenous antibiotics and highdose intravenous immunoglobulin (IVIG).
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- A case of neonatal alloimmune thrombocytopenia related to HLA antibody
- Granulocyte Antibodies in Korean Neonates with Neutropenia
- A case of neonatal alloimmune thrombocytopenia due to anti-HLA B44
- Genotype Frequencies of Platelet Glycoprotein IIIa-Specific Antigens and Granulocyte Antigens In Korean Pregnant Women*
- A Case of Neonatal Alloimmune Neutropenia Associated with Anti-Human Neutrophil Antigen-1a (HNA-1a) Antibody
