J Korean Soc Pediatr Nephrol.  2004 Oct;8(2):149-158.

Expression of Tubular Intercellular Adhesion Molecule-1 (ICAM-1) as a Marker of Renal Injury in Children with IgA Nephropathy

• Son YH
• Kang MS
• Chung WY

Abstract

PURPOSE: In order to evaluate the value of the renal expression of ICAM-1 as a marker of renal injury, we analyzed the relationship between abnormal tubular expression of ICAM-1 and histopathological features and clinical manifestations in children with IgA nephropathy (IgAN).
METHODS
The clinical data from 43 patients with IgAN were analyzed retrospectively and compared to the histopathologic subclassification proposed by Haas. ICAM-1 in tubular epithelium was assessed using the LSAB(Labeled streptavidine biotin) kit on the renal biopsy specimens.
RESULTS
In 43 patients with primary IgAN, 28 males and 15 females aged 12.2+/-2.2 years were studied. There were no differences of renal tubular expression of ICAM-1 between patients with gross hematuria and without gross hematuria. But renal tubular expression of ICAM-1 in patients with proteinuria was significantly higher than that of in patients without proteinuria(78.72+/-14.19% vs. 55.80+/-32.20%, P<0.05). Renal tubular expression of ICAM-1 was also associated with the severity of histopathological degree using Haas classification method. In subclass I, renal tubular expression of ICAM-1 was significantly lower than those of other subclasses. A significant correlation was found between the tubular expression of ICAM-1 and the total amount of protein in 24 hour collected urine(rs=0.47236, P<0.05). But there were no significant correlations between the renal tubular expression of ICAM-1 and interstitial cellular infiltration, tubular atrophy, and interstitial fibrosis respectively(F=0.89, P>0.05; F=0.31, P>0.05; F=0.21, P>0.05).
CONCLUSION
Renal tubular expression of ICAM-1 can be a useful marker of renal injury in children with IgAN.

Keyword

IgA nephropathy; Intercellular adhesion molecule-1; Renal tubule; Predictive marker; Children

MeSH Terms

Atrophy
Biopsy
Child*
Classification
Epithelium
Female
Fibrosis
Glomerulonephritis, IGA*
Hematuria
Humans
Immunoglobulin A*
Intercellular Adhesion Molecule-1*
Male
Proteinuria
Retrospective Studies
Streptavidin
Immunoglobulin A
Intercellular Adhesion Molecule-1
Streptavidin