J Korean Surg Soc.  2003 Nov;65(5):369-376.

Correlation between Expression of CD44, Bcl-2, PCNA, and Apoptosis in Neuroblastoma According to Shimada Histology

• Choi SJ

Abstract

PURPOSE
This study evaluated the correlation between expression level of CD44, bcl-2 and PCNA and the extent of apoptosis in a neuroblastoma according to the Shimada histology. METHODS: Using the neuroblastoma tissue, which was kept at the Chonnam National University Hospital, this study investigated the effect of the CD44, bcl-2, proliferating cell nuclear antigen(PCNA) expression levels and apoptosis according to the Shimada histology. RESULTS: There was significant correlation between the Shimada histology and the CD44 expression level (P= 0.004). There was also a correlation between the Shimada histology and the PCNA expression level (P=0.004). The correlations between the PCNA and CD44 expression levels showed a negative correlation (P<0.01). There was also a significant correlation between the occurrence of apoptosis and the bcl-2 expression level. CONCLUSION: The CD44 and PCNA expression level and the Shimada histology were correlated. Therefore, the Shimada histology, as well as the CD44, and PCNA expression levels are prognostic factors in neuroblastoma. However, a further multicenter study is recommended in order to demonstrate the value of using the Shimada histology, along with the CD44, and PCNA level as prognostic factors in neuroblastoma.

Keyword

Neuroblastoma; CD44; bcl-2; PCNA; Apoptosis; Shimada histology

MeSH Terms

Apoptosis*
Jeollanam-do
Neuroblastoma*
Proliferating Cell Nuclear Antigen*
Proliferating Cell Nuclear Antigen