- LGR5 and Downstream Intracellular Signaling Proteins Play Critical Roles in the Cell Proliferation of Neuroblastoma, Meningioma and Pituitary Adenoma
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Hwang M, Han MH, Park HH, Choi H, Lee KY, Lee YJ, Kim JM, Cheong JH, Ryu JI, Min KW, Oh YH, Ko Y, Koh SH
- KMID: 2463717
- Exp Neurobiol.
- 2019 Oct;28(5):628-641.
- doi: 10.5607/en.2019.28.5.628
Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) has been reported to play critical roles in the proliferation of various cancer cells. However, the roles of LGR5 in brain tumors and... -
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- Differential Clinical Significance of Neurotrophin-3 Expression according to MYCN Amplification and TrkC Expression in Neuroblastoma
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Seo E, Kim JS, Ma YE, Cho HW, Ju HY, Lee SH, Lee JW, Yoo KH, Sung KW, Koo HH
- KMID: 2459423
- J Korean Med Sci.
- 2019 Oct;34(39):e254.
- doi: 10.3346/jkms.2019.34.e254
BACKGROUND: Neurotrophin-3 (NT-3), a member of the NT family, has only been considered an ancillary compound that provides anti-apoptotic benefits by inactivating tropomyosin receptor kinase C (TrkC)-induced apoptotic signals. However,... -
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- Deep learning for stage prediction in neuroblastoma using gene expression data
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Park A, Nam S
- KMID: 2462044
- Genomics Inform.
- 2019 Sep;17(3):e30.
- doi: 10.5808/GI.2019.17.3.e30
Neuroblastoma is a major cause of cancer death in early childhood, and its timely and correct diagnosis is critical. Gene expression datasets have recently been considered as a powerful tool... -
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- Patterns of recurrence after radiation therapy for high-risk neuroblastoma
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Jo JH, Ahn SD, Koh M, Kim JH, Lee SW, Song SY, Yoon SM, Kim YS, Kim SS, Park JH, Jung J, Choi EK
- KMID: 2460748
- Radiat Oncol J.
- 2019 Sep;37(3):224-231.
- doi: 10.3857/roj.2019.00353
PURPOSE: To investigate the patterns of recurrence in patients with neuroblastoma treated with radiation therapy to the primary tumor site. MATERIALS AND METHODS: We retrospectively analyzed patients with high-risk neuroblastoma managed... -
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- Mirror Syndrome Resulting from Metastatic Congenital Neuroblastoma to Placenta
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Park SH, Namgoong J, Ko KN, Kim CJ, Lee PR, Jung E, Lee BS, Kim KS, Kim EA
- KMID: 2430224
- Perinatology.
- 2018 Dec;29(4):189-194.
- doi: 10.14734/PN.2018.29.4.189
Congenital neuroblastoma is a rare disease. Placental metastasis is extremely rare and poor prognosis has been reported in neonates. Mirror syndrome could occur in mother with placental metastasis with possibilities... -
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- Two Cases of Adjuvant Immunotherapy with Cytokine-Induced Killer Cells for Relapsed or Refractory Neuroblastoma
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Choi JY, An HY, Hong KT, Hong C, Kang HJ, Shin HY
- KMID: 2435416
- Clin Pediatr Hematol Oncol.
- 2018 Oct;25(2):202-207.
- doi: 10.15264/cpho.2018.25.2.202
The treatment outcomes of relapsed or refractory neuroblastoma have been unsatisfactory till date. We reported two cases of adoptive immunotherapy using cytokine-induced killer (CIK) cells against relapsed or refractory neuroblastoma.... -
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- Clinical Significance of Random Urinary Vanillylmandelic Acid in Patients with Neuroblastoma
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Park E, Park H, Cho H, Ma Y, Lee SY, Lee JW, Yoo KH, Sung KW, Koo HH
- KMID: 2435406
- Clin Pediatr Hematol Oncol.
- 2018 Oct;25(2):142-148.
- doi: 10.15264/cpho.2018.25.2.142
BACKGROUND: To evaluate the value of random urinary vanillylmandelic acid (VMA) as a surrogate marker for monitoring tumor response and predicting outcome in patients with neuroblastoma (NB). METHODS: Medical records of... -
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- A Case of Infantile Nephrotic Syndrome associated with Neuroblastoma
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Kim SH, Park HM, Lee JH, Kim H, Go H, Kim DY, Park YS
- KMID: 2435378
- Child Kidney Dis.
- 2018 Oct;22(2):91-96.
- doi: 10.3339/jkspn.2018.22.2.91
Nephrotic syndrome in the first year of life, characterized by renal dysfunction and proteinuria, is associated with a heterogeneous group of disorders. These disorders are often related to genetic mutations,... -
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- Value of SPECT/CT in Diagnostic I-131 MIBG Scintigraphy in Patients with Neuroblastoma
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Theerakulpisut D, Raruenrom , Wongsurawat N, Somboonporn C
- KMID: 2422796
- Nucl Med Mol Imaging.
- 2018 Oct;52(5):350-358.
- doi: 10.1007/s13139-018-0532-y
PURPOSE: Diagnostic I-131 MIBG scintigraphy is an important imaging modality for evaluation of patients with neuroblastoma (NB) especially in centers where I-123 MIBG is not available. Single photon emission computed... -
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- ALK Protein Expression Is Related to Neuroblastoma Aggressiveness But Is Not Independent Prognostic Factor
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Lee JW, Park SH, Kang HJ, Park KD, Shin HY, Ahn HS
- KMID: 2411138
- Cancer Res Treat.
- 2018 Apr;50(2):495-505.
- doi: 10.4143/crt.2016.577
PURPOSE: In this study, anaplastic lymphoma kinase (ALK) mutation and amplification, ALK protein expression, loss of the nuclear alpha thalassemia/mental retardation syndrome X-linked (ATRX) protein, and telomerase reverse transcriptase (TERT)... -
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- Prenatally detected thoracic neuroblastoma
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Park Y, Lee HJ, Jung YJ, Lee JH, Kwon JY, Kim YH
- KMID: 2420184
- Obstet Gynecol Sci.
- 2018 Mar;61(2):278-281.
- doi: 10.5468/ogs.2018.61.2.278
Neuroblastoma is the most common pediatric extracranial solid tumor derived from primitive neural crest cells of the sympathetic nervous system. Although one-fifths of all neuroblastomas occurs within the thorax, thoracic... -
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- Excellent treatment outcomes in children younger than 18 months with stage 4 MYCN nonamplified neuroblastoma
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Kim C, Choi YB, Lee JW, Yoo KH, Sung KW, Koo HH
- KMID: 2452041
- Korean J Pediatr.
- 2018 Feb;61(2):53-58.
- doi: 10.3345/kjp.2018.61.2.53
PURPOSE: Although the prognosis is generally good in patients with intermediate-risk neuroblastoma, no consensus has been reached on the ideal treatment regimen. This study analyzed treatment outcomes and toxicities in... -
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- Topotecan-Vincristine-Doxorubicin in Stage 4 High-Risk Neuroblastoma Patients Failing to Achieve a Complete Metastatic Response to Rapid COJEC: A SIOPEN Study
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Amoroso L, Erminio G, Makin G, Pearson AD, Brock P, Valteau-Couanet D, Castel V, Pasquet M, Laureys G, Thomas C, Luksch R, Ladenstein R, Haupt R, Garaventa , SIOPEN Group
- KMID: 2403484
- Cancer Res Treat.
- 2018 Jan;50(1):148-155.
- doi: 10.4143/crt.2016.511
PURPOSE: Metastatic response to induction therapy for high-risk neuroblastoma is a prognostic factor. In the International Society of Paediatric Oncology Europe Neuroblastoma (SIOPEN) HR-NBL-1 protocol, only patients with metastatic complete... -
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- Neuroprotective effects of Momordica charantia extract against hydrogen peroxide-induced cytotoxicity in human neuroblastoma SK-N-MC cells
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Kim KB, Lee S, Heo JH, Kim JH
- KMID: 2395218
- J Nutr Health.
- 2017 Oct;50(5):415-425.
- doi: 10.4163/jnh.2017.50.5.415
PURPOSE: Many studies have suggested that neuronal cells protect against oxidative stress-induced apoptotic cell death by polyphenolic compounds. We investigated the neuroprotective effects and the mechanism of action of Momordica... -
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- Primary Retropharyngeal Neuroblastoma in an Infant: A Case Report with Literature Review
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Lee J, Kim ES, Lee Y, Lee K, Kwon MJ, Moon JH, Kim HJ, Yoon DY
- KMID: 2392125
- J Korean Soc Radiol.
- 2017 Oct;77(4):258-261.
- doi: 10.3348/jksr.2017.77.4.258
Neuroblastoma is a malignant tumor usually occurring in children, which most commonly develops in the abdomen. Primary cervical neuroblastoma has rarely been reported. We present a case of primary retropharyngeal... -
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- Clinical Significance of Pretreatment FDG PET/CT in MIBG-Avid Pediatric Neuroblastoma
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Kang SY, Rahim MK, Kim YI, Cheon GJ, Kang HJ, Shin HY, Kang KW, Chung JK, Kim EE, Lee DS
- KMID: 2446896
- Nucl Med Mol Imaging.
- 2017 Jun;51(2):154-160.
- doi: 10.1007/s13139-016-0451-8
PURPOSE: ¹â¸F-fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging is well known to have clinical significance in the initial staging and response evaluation of the many kinds of neoplasms. However, its role in... -
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- Calcium Signaling of Lysophosphatidylethanolamine through LPA1 in Human SH-SY5Y Neuroblastoma Cells
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Lee JM, Park SJ, Im DS
- KMID: 2375040
- Biomol Ther.
- 2017 Mar;25(2):194-201.
- doi: 10.4062/biomolther.2016.046
Lysophosphatidylethanolamine (LPE), a lyso-type metabolite of phosphatidylethanolamine, has been reported to be an intercellular signaling molecule. LPE mobilizes intracellular Ca²⺠through G-protein-coupled receptor (GPCR) in some cells types. However, GPCRs... -
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- Lamotrigine, an antiepileptic drug, inhibits 5-HT₃ receptor currents in NCB-20 neuroblastoma cells
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Kim KJ, Jeun SH, Sung KW
- KMID: 2371035
- Korean J Physiol Pharmacol.
- 2017 Mar;21(2):169-177.
- doi: 10.4196/kjpp.2017.21.2.169
Lamotrigine is an antiepileptic drug widely used to treat epileptic seizures. Using whole-cell voltage clamp recordings in combination with a fast drug application approach, we investigated the effects of lamotrigine... -
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- Neuroblastoma in a 3-year-old boy presenting with pain in the bilateral hip and abdomen
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Kwon JH, Kim JH, Song IH, Ryu JM
- KMID: 2368378
- Pediatr Emerg Med J.
- 2016 Dec;3(2):59-64.
- doi: 10.22470/pemj.2016.3.2.59
A 3-year-old boy presented to our emergency department with a 3-week history of pain in the bilateral hip and abdomen that had persisted through antibiotic therapy based on diagnosis of... -
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- A Primary Sellar Neuroblastoma Mimicking a Pituitary Adenoma: A Case Report
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Kim DG, Heo YJ, Kim EK, Baek JW, Jeong HW, Jung HS
- KMID: 2360432
- J Korean Soc Radiol.
- 2016 Dec;75(6):450-454.
- doi: 10.3348/jksr.2016.75.6.450
Intracranial neuroblastomas are uncommon malignant tumors that usually arise in the supratentorial parenchymal or paraventricular location. A primary neuroblastoma arising in the sella turcica is extremely rare. We report a... -
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