Korean Circ J.
2005 Mar;35(3):215-220. 10.4070/kcj.2005.35.3.215.
An Insertion/Deletion Polymorphism in the alpha(2B)-Adrenoceptor Gene is not a Genetic Risk Factor for Coronary Artery Disease in the Korean Population
- Affiliations
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- 1BK21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. jangys1212@yumc.yonsei.ac.kr
- 2Cardiovascular Genome Center, Yonsei University College of Medicine, Seoul, Korea.
- 3Department of Biostatistics and Computing, Yonsei University College of Medicine, Seoul, Korea.
- 4Yonsei Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Korea.
- 5Division of Cardiology, Yonsei University College of Medicine, Seoul, Korea.
- KMID: 2093921
- DOI: http://doi.org/10.4070/kcj.2005.35.3.215
Abstract
- BACKGROUND AND OBJECTIVES
Cardiovascular disease (CVD) is a complex multigenic disorder, with significant inheritable elements having important roles relating to environmental factors. Recently, the alpha 2 adrenoceptor (alpha(2)-AR) gene has been reported to be involved in the development of coronary artery disease (CAD). The aim of this study was to investigate the relationships between an insertion/deletion (I/D) in alpha(2B)-AR and CAD in Korean subjects.
SUBJECTS AND METHODS
The alpha(2B)-AR I/D polymorphism, which was located in the third intracellular loop of the receptor polypeptide, was examined in 292 patients (M:F=219:73) with CAD and 151 healthy control subjects (M:F=70:81) who visited the Cardiovascular Genome Center in Yonsei Cardiovascular Hospital.
RESULTS
In the patient group, 77 men (35.1%) and 26 women (35.6%) had the I/I genotype; 105 men (47.9%) and 39 women (53.4%) a heterozygous genotype and 37 (17.0%) and 8 (11.0%) the D/D genotype. In the controls, 23 men (32.8%) and 29 women (35.8%) had the I/I genotype; 38 (54.3%) and 39 (48.1%) the I/D genotype and 9 (12.9%) and 13 (16.1%) the D/D genotype. There were no differences in the genotype frequencies between the patient and control groups, either in men or women. From a logistical regression analysis, the alpha(2B)-AR genotype was not significantly associated with CAD in our study group.
CONCLUSION
The alpha(2B)-AR I/D polymorphism is not a risk factor for CAD in the Korean population.
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