Korean Circ J.  2003 May;33(5):362-373. 10.4070/kcj.2003.33.5.362.

A Comparison of Tenecteplase(TNK-tPA) and Alteplase(rt-PA) in Korean Patients with Acute Myocardial Infarction(A Randomized, Multi-Centered Coronary Angiographic Trial)

• Jeong MH
• Kim W
• Kang JC
• Han SW
• Hur SH
• Kim KB
• Cha KS
• Kim MH
• Kang HS
• Bae JH
• Chae IH
• Oh BH
• Hong MK
• Park SW
• Park SJ
• Choi SY
• Tahk SJ
• Choi DH
• Jang YS
• Cho SY
• Yoo BS
• Yoon JH
• Choe KH

• KMID: 2093874
• DOI: http://doi.org/10.4070/kcj.2003.33.5.362

Abstract

BACKGROUND AND OBJECTIVES
This is a comparative, randomized, multi-centered, angiographic trial for the comparison of TNK-tPA with rt-PA, in Korean patients with an acute myocardial infarction (AMI).
SUBJECTS AND METHODS
Fifty four patients that were eligible for thrombolysis, diagnosed with an AMI, were randomized into two groups:TNK-tPA (single bolus injection, 25-50 mg weight adjusted;n=25) or rt-PA (accelerated intravenous infusion, up to 100 mg;n=29) at the emergency room. The primary endpoint was the percentage of patients with a TIMI (Thrombolysis In Myocardial Infarction) III flow 90 min following the administration of the study drug. The secondary endpoints were an infarct-related artery patency at 90 min, the percentage of patients with ST segment resolution at 60 and 180 min, and at 30 days mortality.
RESULTS
The baseline demographic data, including age, sex and body weight, and a medical history of prior myocardial infarction and risk factors were no different between the TNK-tPA and rt-PA groups. The pain-to-needle and door-to-needle times were also no different. The ST segment resolution was no different between the two groups. A TIMI grade 3, on a coronary angiogram, 90 min following the drug administration, was observed in 19 (76.0%) of the TNK-tPA and 17 (58.6%) of the rt-PA (p=0.24) patients. However, a TIMI grade more than 2 was higher in the TNK-tPA (100%;25/25) than in rt-PA group (72.4%;21/29)(p=0.0052). The in-hospital adverse events, and clinical outcomes at 30 days, were no different between the two groups.
CONCLUSION
TNK-tPA is more convenient, and may be a preferred thrombolytic agent, for the revascularization of an AMI.

Keyword

Coronary disease; Myocardial infarction; Thrombolysis, therapeutic; Myocardial revascularization; Survival

MeSH Terms

Arteries
Body Weight
Coronary Disease
Emergency Service, Hospital
Humans
Infusions, Intravenous
Mortality
Myocardial Infarction
Myocardial Revascularization
Risk Factors
Thrombolytic Therapy