Korean Circ J.  2001 May;31(5):512-512. 10.4070/kcj.2001.31.5.512.

Incidence of eNOS gene mutationin Korean patients with coronary artery spasm

• Kim JH
• Lim BK
• Kim BY
• Lee JW
• Kang JA
• Lim DS
• Lee MS
• Kim YC
• Sung BY
• Choe SC
• Seong IW
• Jeon ES

• KMID: 2093815
• DOI: http://doi.org/10.4070/kcj.2001.31.5.512

Abstract

BACKGROUND: Coronary artery spasm is an important mechanism in producing myocardial ischemia. But the exact mechanism of the spasm is not well known. We investigated the mutation of endothelial nitric oxide synthase (eNOS) that produce nitric oxide and relationship between eNOS mutation and coronary artery spasm.
MATERIALS AND METHODS
Blood were drawn from the patients with angiographically proven coronary artery spasm and normal controls. DNA were extracted and polymerase chain reaction and restriction analysis with Nae I were performed to find T-786--RESULTS
The prevalence of coronary artery spasm in Chungnam National University Hospital was 19% (125/664). The 85 cases of coronary artery spasm and 131 cases of normal control were compared. The men in spasm group were more prevalent than the women (p<0.0001) and rate of smoking were higher in spasm group (p<0.0001). The T-786--CONCLUSION
The T-786--

MeSH Terms

Cholesterol
Chungcheongnam-do
Coronary Vessels*
DNA
Female
Humans
Incidence*
Korea
Male
Myocardial Ischemia
Nitric Oxide
Nitric Oxide Synthase Type III
Polymerase Chain Reaction
Prevalence
Smoke
Smoking
Spasm*
Triglycerides
Cholesterol
DNA
Nitric Oxide
Nitric Oxide Synthase Type III
Smoke