Korean J Anesthesiol.  2005 Jan;48(1):29-32. 10.4097/kjae.2005.48.1.29.

Action Duration of Rocuronium in the Elderly Patients

• Choi WJ
• Lim YJ
• Lee YK
• Hahm KD
• Yang HS

• KMID: 2091951
• DOI: http://doi.org/10.4097/kjae.2005.48.1.29

Abstract

BACKGROUND: The effect of a muscle relaxant may differ in the elderly for pharmacokinetic and pharmacodynamic reasons. Rocuronium, a derivative of vecuronium is a non depolarizing neuromuscular blocker with a rapid onset and intermediate duration. The purpose of this study was to compare differences in the onset and duration of rocuronium in young adults and the elderly.
METHODS
The study was approved by our instituitional review board, and informed consent was obtained from all patients. Twenty two young adults (15 59 yr) and 21 elderly (65 80 yr) patients, ASA physical status 1 2 underwent elective orthopedic surgery under general anesthesia. All were anesthetized with pentothal sodium, nitrous oxide, and isoflurane. Rocuronium (0.6 mg/kg) was given and then intubation was performed after TOF response had totally disappeared. Neuromuscular relaxation was measured by TOF response at the adductor pollicis muscle after a supramaximal stimulation of Train-of-four (TOF, 2 Hz every 12 sec) at the ulnar nerve. Onset (disappearance of T1) and the recovery times of T1, T2, T3 and T4 were recorded.
RESULTS
The onset of neuromuscular block was slower in the elderly than the young adults (P < 0.05), and recovery times of T1, T2, T3, and T4 were prolonged in the elderly (P < 0.05).
CONCLUSIONS
Rocuronium has a slower onset time and a delayed recovery in the elderly.

Keyword

geriatrics; rocuronium

MeSH Terms

Aged*
Anesthesia, General
Geriatrics
Humans
Informed Consent
Intubation
Isoflurane
Neuromuscular Blockade
Nitrous Oxide
Orthopedics
Relaxation
Sodium
Thiopental
Ulnar Nerve
Vecuronium Bromide
Young Adult
Isoflurane
Nitrous Oxide
Sodium
Thiopental
Vecuronium Bromide