Korean J Anesthesiol.  2001 Dec;41(6):707-712. 10.4097/kjae.2001.41.6.707.

Effect of Intravenous Clonidine-Fentanyl on Prevention of Postepidural Shivering

• Shin YS

• KMID: 2091637
• DOI: http://doi.org/10.4097/kjae.2001.41.6.707

Abstract

BACKGROUND: The purpose of this study was to evaluate the efficacy of intravenous clonidine-fentanyl to prevent postepidural shivering in patients undergoing an elective orthopedic surgery.
METHODS
Forty ASA class 1 or 2 patients who received epidural anesthesia for an orthopedic surgery were allocated randomly to two groups. 10 min before epidural anesthesia group 1 received intravenous clonidine 2.0ng/kg and group 2 received clonidine 1.0ng/kg and fentanyl 1.0ng/kg shivering was determined objectively by observing involuntary muscle activity. Mean arterial pressure, heart rate and sedation score were measured at 5 minute intervals during the first 30 minutes following epidural anesthesia.
RESULTS
There were no significant differences between the two groups in the occurrence of shivering, hemodynamic changes and sedation score.
CONCLUSIONS
Intravenous clonidine 2.0ng/kg and the combination of clonidine 1.0ng/kg and fentanyl 1.0ng/kg were not significantly different in occurrence of postepidural shivering. Therefore, a combination of small doses of intravenous clonidine and fentanyl may be safe and useful to reduce postepidural shivering.

Keyword

Analgesics: fentanyl; Anesthetic technique: epidural; Complications: shivering; Sympathetic nervous system: pharmacology; clonidineList

MeSH Terms

Anesthesia, Epidural
Arterial Pressure
Clonidine
Fentanyl
Heart Rate
Hemodynamics
Humans
Muscle, Smooth
Orthopedics
Shivering*
Clonidine
Fentanyl