Korean J Anesthesiol.  1999 Apr;36(4):703-709. 10.4097/kjae.1999.36.4.703.

The Effects of Stellate Ganglion Block on the Level of Blood Glucose, Uric Acid, and Catecholamines in the Induced Diabetic Rat

• Chang SH
• Lim HJ
• Yoon HD
• Jeon SY
• Lee HW
• Cho H
• Yoon SM

• KMID: 2091391
• DOI: http://doi.org/10.4097/kjae.1999.36.4.703

Abstract

BACKGROUND: Stellate ganglion block (SGB) has been used to treat over 150 diseases which include diabetes mellitus and gout. This study was planned to investigate whether stellate ganglion block (SGB) could lower the levels of blood glucose, uric acid, epinephrine, and norepinephrine.
METHODS
Sixty Sprague-Dawley rats within the weight of 250-350 gm were randomly devided into four groups. CS group was normal group with sham SGB with normal saline, CL group was normal group with SGB with lidocaine, DS group was diabetic group with SGB with normal saline, DL group was diabetic group with SGB with lidocaine. The diabetes was induced by intraperitoneal injection of 40 mg/kg of streptozotocin in citrate buffer (0.01 M, pH 4.5). Nondiabetic groups were given same amount of the citrate buffer. Seven days after the last injection of the streptozotocin blood glucose level was checked and more than 300 mg/dl was considered diabetic. The SGB was performed three times at right superior cervical ganglion two days apart from two days after the conformation of diabetes. Successful SGB was conformed by the ipsilateral ptosis or conjunctival congestion. Blood samplings from tail vein for the check of glucose, uric acid, and catecholamines were done before the injection of streptozotocin, seven days after the last injection of streptozotocin, and two days after the last SGB.
RESULTS
The SGB with lidocaine reduced the blood glucose level only in the diabetic rats while SGB with the saline did not. The epinephrine levels were increased in the diabetics and decreased by the SGB with lidocaine without any statistical significance. Norepinephrine and uric acid levels had not been effected by the SGB and both of them had no correlationship with the glucose level.
CONCLUSIONS
SGB in the diabetic rats decreases the blood glucose level. But for the effects of the SGB on the level of epinephrine further study would be needed.

Keyword

Blood, epinephrine, glucose, norepinephrine, uric acid; Nerve block, technique, SGB

MeSH Terms

Animals
Blood Glucose*
Catecholamines*
Citric Acid
Diabetes Mellitus
Epinephrine
Estrogens, Conjugated (USP)
Glucose
Gout
Hydrogen-Ion Concentration
Injections, Intraperitoneal
Lidocaine
Norepinephrine
Rats*
Rats, Sprague-Dawley
Stellate Ganglion*
Streptozocin
Superior Cervical Ganglion
Uric Acid*
Veins
Blood Glucose
Catecholamines
Citric Acid
Epinephrine
Estrogens, Conjugated (USP)
Glucose
Lidocaine
Norepinephrine
Streptozocin
Uric Acid