Korean J Blood Transfus.
2004 Jun;15(1):45-50.
A Case of A1B3 Child from a Group A Mother and a Group B Father: New Group B Allele Arising from 547G>A
- Affiliations
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- 1Department of Laboratory Medicine, Seonam University Hospital, Korea.
- 2Department of Laboratory Medicine, Chonnam National University Hospital, Korea. dwryang@chonnam.ac.kr
- 3Gwangju-Chonnam Red Cross Blood Center, Gwangju, Korea.
- 4Department of Laboratory Medicine, Samsung Medical Center, Seoul, Korea.
Abstract
- Group B subtype, A1B3, was observed in a 22-year-old blood donors by conventional serologic test. In our family study, his father demonstrated uncomplicated B phenotype and his mother typed as group A. We sequenced exon 6 and 7 of phenotypically A1B3 propositus and his family members by direct sequencing and PCR-based cloning. And we have identified a novel Bvar allele characterized by a 547G>A polymorphism present in propositus and his father. This suggests that the Bvar allele is expressed differently depending on the co-inherited ABO allele.
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