Korean J Clin Pathol.  2000 Aug;20(4):360-363.

1 Case of Primary Plasma Cell Leukemia associated with Esophageal Cancer

• Ha JS
• Kim EJ
• Chun HJ
• Kim JR
• Jeon DS

Abstract

He died after 2 months from diagnosis due to massive bleeding in esophageal lesion with complication. He died after 2 months from diagnosis due to massive bleeding in esophageal lesion with complication. We report one case of plasma cell leukemia associated with esophageal cancer. A 71-year-old man was admitted due to dysphagia and diagnosed as undifferentiated squamous cell cancer based on esophagogram and biopsy. In peripheral blood smear, large parcent of plasma cell like cells are found, so bone marrow examination was done and 52.5% of plasma cells are found with unusual morphology such as convoluted, multilobulated nuclei. Immunochemical stain and immunophenotypic features of these cells were suggestive of plasma cell origin with positivity for methylgreen pyronin positivity and CD38, CD56 positivity. Serum rotein electrophoresis and immunoelectrophoresis showed monoclonal gammopathy of Ig G ,k type. This patient had no history of previous multiple myeloma or other maligancy. He died after 2 months from diagnosis due to massive bleeding in esophageal lesion with complication.

Keyword

plasma cell leukemia; atypical form; CD38; CD56

MeSH Terms

Aged
Biopsy
Bone Marrow Examination
Deglutition Disorders
Diagnosis
Electrophoresis
Esophageal Neoplasms*
Hemorrhage
Humans
Immunoelectrophoresis
Leukemia, Plasma Cell*
Multiple Myeloma
Neoplasms, Squamous Cell
Paraproteinemias
Plasma Cells*
Plasma*