Blood Res.  2017 Dec;52(4):324-326. 10.5045/br.2017.52.4.324.

A case of primary plasma cell leukemia exhibiting hemophagocytic plasma cells relapsed with multiple cutaneous plasmacytoma

• Hwang N
• Ham JY
• Suh JS

• KMID: 2405073
• DOI: http://doi.org/10.5045/br.2017.52.4.324

Abstract

No abstract available.

MeSH Terms

Leukemia, Plasma Cell*
Plasma Cells*
Plasma*
Plasmacytoma*

Figure

• 

  Fig. 1 Hemophagocytic plasma cells and abnormal karyotyping result. (A) Microscopic examination of bone marrow (BM) showing large, bizarre plasma cells with characteristic hemophagocytic features mostly with mature erythrocytes and platelets (Wright-Giemsa staining, ×1,000). (B) Conventional BM chromosome analysis result showing 45,X,−X,+1,dic(1;8)(p13;p23),del(6)(q22q25), del(8)(p21) karyotype.

• 

  Fig. 2 Multiple skin nodules and their biopsy showing infiltration of plasma cells. Multiple skin nodules in the patient's extremities (A). Biopsy of the skin-infiltrating plasma cells showing positive immunohistochemical staining for CD138 (B) and lambda light-chain (C) (×200).

Reference

1. Deng S, Xu Y, An G, et al. Features of extramedullary disease of multiple myeloma: high frequency of p53 deletion and poor survival: a retrospective single-center study of 834 cases. Clin Lymphoma Myeloma Leuk. 2015; 15:286–291. PMID: 25640025.

2. Swerdlow SH, Campo E, Harris NL, editors. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon, France: IARC Press;2008.

3. Invernizzi R, Pecci A. A case of phagocytic multiple myeloma. Haematologica. 2000; 85:318. PMID: 10702823.

4. Kanoh T, Saigo K. Phagocytic myeloma cells in asymptomatic multiple myeloma. Tohoku J Exp Med. 1987; 153:207–210. PMID: 3433276.

5. Kucukkaya RD, Hacihanefioglu A, Yenerel MN, et al. CD15-expressing phagocytic plasma cells in a patient with multiple myeloma. Blood. 2001; 97:581–583. PMID: 11202432.

6. Ludwig H, Pavelka M. Phagocytic plasma cells in a patient with multiple myeloma. Blood. 1980; 56:173–176. PMID: 7397375.

7. Ramos J, Lorsbach R. Hemophagocytosis by neoplastic plasma cells in multiple myeloma. Blood. 2014; 123:1634. PMID: 24761451.

8. Savage DG, Zipin D, Bhagat G, Alobeid B. Hemophagocytic, non-secretory multiple myeloma. Leuk Lymphoma. 2004; 45:1061–1064. PMID: 15291368.

9. Fernández de, Kyle RA, Durie BG, et al. Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group. Leukemia. 2013; 27:780–791. PMID: 23288300.

10. Jurczyszyn A, Olszewska-Szopa M, Hungria V, et al. Cutaneous involvement in multiple myeloma: a multi-institutional retrospective study of 53 patients. Leuk Lymphoma. 2016; 57:2071–2076. PMID: 26726867.

11. Requena L, Kutzner H, Palmedo G, et al. Cutaneous involvement in multiple myeloma: a clinicopathologic, immunohistochemical, and cytogenetic study of 8 cases. Arch Dermatol. 2003; 139:475–486. PMID: 12707095.