Korean J Dermatol.  1999 Feb;37(2):229-233.

A Case of Non-nasal T/NK-cell Lymphoma Occurring in A Patient with Autiphospholipid Syndrome

• Kim JW
• Kim SS
• Kim KJ
• Kim JM
• Lee CJ
• Shin HK

Abstract

Non-nasal T/NK-cell lymphoma(TNKCL) without nasal cavity invasion is a subtype of angiocentric T-cell lymphomas showing the biphenotype of the T-cell and NK-cell. This tumor is characterized by the absence of clonal rearrangement of the T-cell receptor gene, frequent association with Epstein- Barr virus(EBV), poor clinical course, and common extranodal invasion. Antiphospholipid syndrome (APS) is characterized by repetitive spontaneaus abortion, thrombocytopenia, thrombotic symptoms and the positivity to the antiphospholipid antibody. Our patient was a 35-year-old woman with skin lesion on her face. Previously, she had been diagnosed of APS. Histopathological, immunohistochemical and serologic studies could disclose EBV-associated non-nasal TNKCL.

Keyword

Non-nasal T/NK-cell lymphoma; Antiphospholipid syndrome

MeSH Terms

Adult
Antibodies, Antiphospholipid
Antiphospholipid Syndrome
Female
Genes, T-Cell Receptor
Humans
Lymphoma*
Lymphoma, T-Cell
Nasal Cavity
Skin
T-Lymphocytes
Thrombocytopenia
Antibodies, Antiphospholipid